PMID: 9183743Jun 20, 1997Paper

The central pathway of primary olfactory axons is abnormal in mice lacking the N-CAM-180 isoform

Journal of Neurobiology
Helen B TreloarB Key

Abstract

Although N-CAM has previously been implicated in the growth and fasciculation of axons, the development of axon tracts in transgenic mice with a targeted deletion of the 180-kD isoform of the neural cell adhesion molecule (N-CAM-180) appears grossly normal in comparison to wild-type mice. We examined the organization of the olfactory nerve projection from the olfactory neuroepithelium to glomeruli in the olfactory bulb of postnatal N-CAM-180 null mutant mice. Immunostaining for olfactory marker protein revealed the normal presence of fully mature primary olfactory neurons within the olfactory neuroepithelium of mutant mice. The axons of these neurons form an olfactory nerve, enter the nerve fiber layer of the olfactory bulb, and terminate in olfactory glomeruli as in wild-type control animals. The olfactory bulb is smaller and the nerve fiber layer is relatively thicker in mutants than in wild-type mice. Previous studies have revealed that the plant lectin Dolichos biflorus agglutinin (DBA) clearly stains the perikarya and axons of a subpopulation of primary olfactory neurons. Thus, DBA staining enabled the morphology of the olfactory nerve pathway to be examined at higher resolution in both control and mutant animals. Despite ...Continue Reading

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Citations

Jul 9, 1999·The Journal of Comparative Neurology·J Tenne-Brown, B Key
Mar 29, 2002·The Journal of Comparative Neurology·Winnie W AuCharles A Greer
Jul 12, 2001·The Journal of Comparative Neurology·J A St John, B Key
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Jul 31, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Helen B TreloarCharles A Greer
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