The central pattern generator for vomiting may exist in the reticular area dorsomedial to the retrofacial nucleus in dogs

Experimental Brain Research
T KogaH Fukuda

Abstract

There is some controversy over whether or not a discrete site that integrates vomiting activities in somatic and autonomic nerves is present in the medulla oblongata. On the basis of our previous studies, we hypothesized that the temporal patterns of muscle contractions in vomiting are generated by a central pattern generator in the retrofacial area of the rostral medulla. To investigate this hypothesis further, the effects of electrical and chemical lesions of the medullary area were observed in decerebrate paralyzed dogs. Efferent activities of the phrenic and abdominal muscle nerves were recorded to recognize fictive vomiting. The right half of the medulla oblongata was transversely severed about 3 mm rostral to the obex. Fictive vomiting responses to vagal stimulation still appeared after hemisection in all 11 dogs. In addition, stimulation of the contralateral reticular area dorsomedial to the retrofacial nucleus produced fictive vomiting even after hemisection. An electrical lesion or injection of kainic acid (0.5-1.0 microl) was applied at the point where reticular stimulation induced fictive vomiting. After this destruction, no activities that corresponded to fictive vomiting could be induced by stimulation of vagal aff...Continue Reading

Citations

Dec 31, 2002·Brain Research·Tomoshige KogaRyuji Matsuo
Sep 8, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer D MoyAndrew A McCall
Nov 13, 2015·Epilepsy & Behavior : E&B·Nicola PietrafusaNicola Specchio
Dec 26, 2001·The American Journal of Medicine·P J Hornby
Sep 12, 2015·The Journal of Comparative Neurology·Gert Holstege, Hari H Subramanian
Apr 9, 2008·Autonomic Neuroscience : Basic & Clinical·Chiharu KurozumiTomoshige Koga
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Feb 9, 2010·The Journal of Small Animal Practice·C ElwoodK Savary-Bataille
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Sep 12, 2017·Journal of Integrative Neuroscience·Michael George Zaki Ghali
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Aug 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Louiza Belkacemi, Nissar A Darmani

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