PMID: 5921540May 1, 1966

The central release of acetylcholine during stimulation of the visual pathway

The Journal of Physiology
B Collier, J F Mitchell


1. In rabbits anaesthetized with Dial ACh has been collected from the surface of the cerebral cortex during stimulation of the visual pathways.2. The spontaneous release of ACh from the visual and non-visual areas of the cortex was found to be similar.3. Stimulation of the retinae by diffuse light produced a large increase in ACh release from the primary visual receiving areas (4.3 times the spontaneous release) and a smaller increase (1.9 times the spontaneous release) from other parts of the cortex.4. Direct unilateral electrical stimulation of the lateral geniculate body evoked a large increase in ACh release (3.4 times the spontaneous release) from the ipsilateral visual cortex and a smaller increase (1.7 times the spontaneous release) from the contralateral visual area and other regions of the cerebral cortex. The evoked increase from the contralateral cortex was not mediated by transcallosal pathways.5. The increase in ACh release evoked from the visual cortex by stimulation of the ipsilateral lateral geniculate body was dependent on the frequency of stimulation. The evoked release was smallest at low stimulus frequencies and increased to a maximum at 20 stimuli/sec. The evoked ACh release from other areas of the cortex w...Continue Reading


Apr 1, 1971·Agents and Actions·C K Erickson, W L Burnam
Jul 1, 1968·International Journal of Neuropharmacology·L W Chakrin, F E Shideman
Jul 1, 1968·International Journal of Neuropharmacology·L W ChakrinA S Marrazzi
Sep 1, 1968·International Journal of Neuropharmacology·L BeaniP Marchetti
Sep 23, 2000·Behavioural Brain Research·D D Rasmusson
Feb 1, 1997·Brain Research. Brain Research Reviews·M Sarter, J P Bruno
Jan 1, 1974·Drug Metabolism Reviews·P D Hrdina
Feb 15, 2011·Behavioural Brain Research·Lianne RobinsonGernot Riedel
Dec 1, 2010·Pharmacology, Biochemistry, and Behavior·Bruce E Hetzler, Elizabeth J Beckman
Jun 23, 2004·Neuroscience·G N FournierD D Rasmusson
Feb 1, 1971·Experimental Neurology·N Chu, L T Rutledge
Dec 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bruce E Hetzler, Alison M Bauer
Jan 1, 1969·British Journal of Pharmacology·A K ArmitageC M Sellers
Nov 1, 1968·British Journal of Pharmacology·B A Hemsworth, M J Neal
Jun 20, 1984·The Journal of Comparative Neurology·J C HedreenD L Price
Jun 15, 1986·The Journal of Comparative Neurology·C Shaw, M Cynader
Dec 1, 1972·Journal of Neurochemistry·L W ChakrinV P Whittaker
May 1, 1969·British Journal of Pharmacology·B A Hemsworth, J F Mitchell
Dec 17, 2019·Restorative Neurology and Neuroscience·Elvire VaucherMira Chamoun
Jun 27, 2019·Progress in Retinal and Eye Research·Muneeb A FaiqKevin C Chan

Related Concepts

Acetylcholine Sulfate (1: 1)
Anesthetic Effect
Vigilance, Cortical
Insula of Reil
Electric Stimulation Technique
Medial Geniculate Body

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.