PMID: 5921540May 1, 1966

The central release of acetylcholine during stimulation of the visual pathway

The Journal of Physiology
B Collier, J F Mitchell

Abstract

1. In rabbits anaesthetized with Dial ACh has been collected from the surface of the cerebral cortex during stimulation of the visual pathways.2. The spontaneous release of ACh from the visual and non-visual areas of the cortex was found to be similar.3. Stimulation of the retinae by diffuse light produced a large increase in ACh release from the primary visual receiving areas (4.3 times the spontaneous release) and a smaller increase (1.9 times the spontaneous release) from other parts of the cortex.4. Direct unilateral electrical stimulation of the lateral geniculate body evoked a large increase in ACh release (3.4 times the spontaneous release) from the ipsilateral visual cortex and a smaller increase (1.7 times the spontaneous release) from the contralateral visual area and other regions of the cerebral cortex. The evoked increase from the contralateral cortex was not mediated by transcallosal pathways.5. The increase in ACh release evoked from the visual cortex by stimulation of the ipsilateral lateral geniculate body was dependent on the frequency of stimulation. The evoked release was smallest at low stimulus frequencies and increased to a maximum at 20 stimuli/sec. The evoked ACh release from other areas of the cortex w...Continue Reading

Citations

Apr 1, 1971·Agents and Actions·C K Erickson, W L Burnam
Jul 1, 1968·International Journal of Neuropharmacology·L W Chakrin, F E Shideman
Jul 1, 1968·International Journal of Neuropharmacology·L W ChakrinA S Marrazzi
Sep 1, 1968·International Journal of Neuropharmacology·L BeaniP Marchetti
Sep 23, 2000·Behavioural Brain Research·D D Rasmusson
Feb 1, 1997·Brain Research. Brain Research Reviews·M Sarter, J P Bruno
Jan 1, 1974·Drug Metabolism Reviews·P D Hrdina
Feb 15, 2011·Behavioural Brain Research·Lianne RobinsonGernot Riedel
Dec 1, 2010·Pharmacology, Biochemistry, and Behavior·Bruce E Hetzler, Elizabeth J Beckman
Jun 23, 2004·Neuroscience·G N FournierD D Rasmusson
Feb 1, 1971·Experimental Neurology·N Chu, L T Rutledge
Dec 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bruce E Hetzler, Alison M Bauer
Jan 1, 1969·British Journal of Pharmacology·A K ArmitageC M Sellers
Nov 1, 1968·British Journal of Pharmacology·B A Hemsworth, M J Neal
Jun 20, 1984·The Journal of Comparative Neurology·J C HedreenD L Price
Jun 15, 1986·The Journal of Comparative Neurology·C Shaw, M Cynader
Dec 1, 1972·Journal of Neurochemistry·L W ChakrinV P Whittaker
May 1, 1969·British Journal of Pharmacology·B A Hemsworth, J F Mitchell
Dec 17, 2019·Restorative Neurology and Neuroscience·Elvire VaucherMira Chamoun
Jun 27, 2019·Progress in Retinal and Eye Research·Muneeb A FaiqKevin C Chan

Related Concepts

Acetylcholine Sulfate (1: 1)
Anesthetic Effect
Vigilance, Cortical
Insula of Reil
Electric Stimulation Technique
Medial Geniculate Body
Vision

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