The Central Role for Microenvironment in B-Cell Malignancies: Recent Insights into Synergistic Effects of its Therapeutic Targeting and Anti-CD20 Antibodies

International Reviews of Immunology
Vahideh AhmadzadehNasser Pouladi

Abstract

Most B-cell-related disorders can be cured with conventional agents; however, relapse is common, creating a need for additional therapeutic options. In agreement, recent biomarker studies corroborate the role played by functional crosstalk between malignant B cells and microenvironment which have added texture to clinical outcome. Here we outline the essential role of the tumor-associated niche in B-cell Lymphoma/Leukemia pathogenesis, in an attempt to optimize the use of microenvironment-targeted drugs and anti-CD20 antibodies in the various subsets.

References

Sep 1, 1994·Immunology Today·T F Tedder, P Engel
May 1, 2002·European Journal of Immunology·Paolo GhiaFederico Caligaris-Cappio
May 31, 2002·Blood·Brian F Skinnider, Tak W Mak
Nov 12, 2003·The Journal of Experimental Medicine·Marcel SpaargarenSteven T Pals
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ellen J SchletteGeorge Z Rassidakis
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marta CrespoFrancesc Bosch
Jul 11, 2006·Immunology·Stéphanie HaiatJean-Pierre Kolb
Sep 12, 2007·Blood·Frida LantnerIdit Shachar
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Myron S CzuczmanFrancisco J Hernandez-Ilizaliturri
Jun 13, 2009·British Journal of Haematology·Jonathan W FriedbergArnold S Freedman
Jun 30, 2009·Nature Immunology·Pilar DelgadoBalbino Alarcón
Jul 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Georg HessBertrand Coiffier
Dec 10, 2009·British Journal of Haematology·Rainer HubmannMedhat Shehata
Dec 30, 2009·The Journal of Clinical Investigation·Taco W KuijpersRené A W van Lier
Jan 29, 2010·Seminars in Immunopathology·Michelle A Linterman, Carola G Vinuesa
Feb 17, 2010·The Journal of Experimental Medicine·David R GibbDaniel H Conrad
Apr 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Inbal BinskyIdit Shachar
May 27, 2010·Cancer Research·Maite P Quiroga, Jan A Burger
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Vania CoelhoFreda K Stevenson
Dec 22, 2010·American Journal of Clinical Pathology·Paul N MeyerDennis D Weisenburger
Dec 24, 2010·Science Translational Medicine·Mark P ChaoIrving L Weissman
Dec 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jia RuanJohn P Leonard
Mar 18, 2011·Science Translational Medicine·Bart BuringtonDavid Dornan

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Citations

Feb 23, 2021·Journal of Drug Targeting·Mohammad Reza KhirehgeshBahman Akbari

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