PMID: 15379656Sep 24, 2004Paper

The central role of angiotensin I-converting enzyme in vertebrate pathophysiology

Current Topics in Medicinal Chemistry
David W Moskowitz, Frank E Johnson

Abstract

Genomic epidemiologic data, increasingly supported by clinical outcomes results, strongly suggest that overactivity of angiotensin I-converting enzyme (ACE) may underlie most age-related diseases. Angiotensin II, the main product of ACE, is a pleiotropic hormone, capable of serving as a neurotransmitter, growth factor, angiogenesis factor, vasoconstrictor, pro-thrombotic agent, and cytokine. So it is perhaps not surprising that the ACE D/D genotype is associated with several major psychiatric diseases, most cancers except prostate cancer (where the D/D genotype is actually protective), most cardiovascular diseases, most autoimmune diseases, and even infectious diseases like tuberculosis and HIV. In a preliminary study, angiotensin II blockade appeared to hasten recovery from West Nile virus encephalitis; it may be equally useful in SARS. The ACE gene underwent duplication at the origin of Chordata, just before the "Cambrian Explosion" in the number of species. The ancestral, unduplicated form of ACE is still expressed during the terminal differentiation of human spermatocytes, suggesting a critical role in reproduction. The crystal structure of testicular ACE (tACE) was recently published. Computer modeling suggests that tACE m...Continue Reading

Citations

Mar 3, 2006·The New England Journal of Medicine·David W Moskowitz
Jul 6, 2014·Drug Discovery Today·Katarzyna RegulskaMarek Murias
Dec 19, 2008·The American Journal of the Medical Sciences·Eric M MortensenAntonio Anzueto
Apr 23, 2011·Research in Social & Administrative Pharmacy : RSAP·Abhishek S ChitnisMichael L Johnson
Aug 18, 2005·International Journal of Cancer. Journal International Du Cancer·M Ahmad Chaudhry
Jul 12, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·James A Crowell
Dec 22, 2005·International Journal of Clinical Oncology·Hiroji UemuraYoshinobu Kubota
May 10, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Taejong SongSeok Ju Seong
Mar 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Silvia Moriano-GutierrezMargaret J McFall-Ngai
Mar 21, 2020·Cell Discovery·Yadi ZhouFeixiong Cheng
Mar 17, 2021·Cell Discovery·Yadi ZhouFeixiong Cheng
Mar 26, 2021·Journal of Evidence-based Integrative Medicine·Zemene Demelash KifleAbebe Basazn Mekuria
Aug 3, 2021·Virusdisease·Zahra Setayesh-Mehr, Mahdiye Poorsargol

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