PMID: 8487193Jan 1, 1993Paper

The central role of corticotrophin-releasing factor (CRF-41) in psychological stress in rats

The Journal of Physiology
A MorimotoN Murakami

Abstract

1. We investigated the central role of corticotrophin-releasing factor (CRF-41) in psychological stress-induced responses, including cardiovascular, thermoregulatory and locomotive activity in free-moving rats. 2. Psychological stress was induced by cage-switch stress. After rats were placed in the novel environment, blood pressure, heart rate, body temperature and locomotive activity significantly increased. The intracerebroventricular (I.C.V.) injection of alpha-helical CRF(9-41), a CRF-41 receptor antagonist, significantly attenuated the stress-induced hypertension, tachycardia, hyperthermia and increase in locomotive activity. However, in unstressed rats, the I.C.V. injection of alpha-helical CRF(9-41) had no effect on physiological parameters measured in this study. 3. In unstressed rats, the I.C.V. injection of CRF-41 (1 microgram and 10 micrograms) increased blood pressure, heart rate, body temperature and locomotive activity in a dose-dependent manner. The changes in these responses were quite similar to those observed during cage-switch stress. 4. The results suggest that central CRF-41 plays an important role in psychological stress-induced hypertension, hyperthermia, tachycardia and increase in locomotive activity. H...Continue Reading

Citations

Feb 22, 2003·CNS Drug Reviews·Patricia A SeymourDavid W Schulz
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Keiko MorimotoKen-Ichi Yoshida
Sep 3, 2004·Behavioural Pharmacology·A Badiani, T E Robinson
Sep 6, 2005·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Katsuya SakimuraTsuneyuki Yamamoto
Dec 15, 2006·Pain Practice : the Official Journal of World Institute of Pain·K VissersT Meert
Sep 29, 2015·Stress : the International Journal on the Biology of Stress·Reka NatarajanBryan K Yamamoto
Jan 1, 1999·Nutritional Neuroscience·M CabanacC Gosselin
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Takakazu Oka
Oct 22, 2008·Molecular Neurobiology·Cynthia L BetheaJudy L Cameron
May 8, 2009·The Journal of Veterinary Medical Science·Ken-Ichi YayouShuichi Ito
Jan 29, 2011·Developmental Psychobiology·Phyllis E Mann, Kristen J Gervais
Feb 18, 2018·Journal of the American Heart Association·Brandon M FoxJennifer S Pollock
Apr 13, 2018·Journal of Neuroendocrinology·A L HeckC E Roselli
Feb 22, 2001·Endocrinology·M J CullenM A Pelleymounter
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cynthia L Bethea, Maria Luisa Centeno
Nov 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shoko TazumiKeiko Morimoto
Jun 24, 2004·Expert Opinion on Investigational Drugs·Eric P Zorrilla, George F Koob
Jul 7, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Sayuki KitagawaKen-ichi Yayou
Aug 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dexter L LeeMichael W Brands
Dec 26, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Mikito Takefuji, Toyoaki Murohara
Apr 5, 2018·Frontiers in Behavioral Neuroscience·Sandy KoenigChristoph Rummel
Aug 4, 2004·Hypertension·Dexter L LeeMichael W Brands
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Neha FallsVikas Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.