The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection

Frontiers in Cellular and Infection Microbiology
Liu ChunfaXiangmei Zhou

Abstract

Mycobacterium bovis (M. bovis) is the pathogen of animals and humans that can replicate in the phagosomes of myeloid cells. Cytosolic detection of bacterial products plays a crucial role in initiating the innate immune response, including autophagy activation and interferon-β (IFN-β) release. Although IFN-β release and autophagy activation have been reported during mycobacterium infection, the mechanisms underlying remains poorly defined. Here, we demonstrated that IFN-β release increases in macrophages exposed to M. bovis and this requires the activation of the DNA sensor of interferon-γ inducible protein 204 (IFI204). Knockdown of the IFI204 in immortalized and primary murine macrophages blocked IFN-β production and autophagy marker LC3 expression. Thus, our results indicate that the IFI204 is an important sensor for innate immune responses of M. bovis infection.

References

Oct 5, 2010·Nature Immunology·Leonie UnterholznerAndrew G Bowie
Jun 15, 2012·International Immunology·Hiroyuki SaigaKiyoshi Takeda
Oct 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eliseo F CastilloVojo Deretic
Mar 23, 2013·Annual Review of Immunology·Anne O'GarraMatthew P R Berry
Feb 25, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kelly M StorekDenise M Monack
Jun 7, 2015·Cell Host & Microbe·Angela C CollinsMichael U Shiloh
Jun 13, 2015·Cell Host & Microbe·Laleh Majlessi, Roland Brosch
Jun 15, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Colleen ScottPatrick K Moonan
Jul 14, 2016·Oncotarget·Chunfa LiuXiangmei Zhou

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Citations

Mar 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dallas A BanksVolker Briken
Feb 7, 2020·Physiology·Benoit BriardThirumala-Devi Kanneganti
Aug 6, 2020·Viruses·Eileen A Moran, Susan R Ross
Sep 10, 2019·The Journal of Infectious Diseases·Yinjuan SongXiangmei Zhou
Mar 2, 2018·International Journal of Molecular Sciences·Tanja ZöllerBjörn Spittau
Dec 18, 2020·Frontiers in Immunology·Ayesha ZahidTengchuan Jin
May 22, 2021·Veterinary Microbiology·Yi LiaoXiangmei Zhou
Sep 11, 2021·Frontiers in Immunology·James P BarrettDavid J Loane

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Methods Mentioned

BETA
acetylation
nuclear translocation
Protein
ELISA
transfections
PCR
biopsy

Software Mentioned

MoSTRCUK
SPSS

Related Concepts

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