The centrosome protein AKNA regulates neurogenesis via microtubule organization

Nature
Germán Camargo OrtegaMagdalena Götz

Abstract

The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors1 that delaminate and settle in the subventricular zone in enlarged brain regions2. The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Here we show that the interphase centrosome protein AKNA has a key role in this process. AKNA localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells, and in almost all basal progenitors. This protein is necessary and sufficient to organize centrosomal microtubules, and promote their nucleation and growth. These features of AKNA are important for mediating the delamination process in the formation of the subventricular zone. Moreover, AKNA regulates the exit from the subventricular zone, which reveals the pivotal role of centrosomal microtubule organization in enabling cells to both enter and remain in the subventricular zone. The epithelial-to-mesenchymal transition is also regulated by AKNA in other epi...Continue Reading

References

Mar 29, 2008·Molecular and Cellular Neurosciences·Luisa PintoMagdalena Götz
Feb 18, 2011·Journal of Cell Science·Miho IbiMasaki Inagaki
Oct 5, 2011·Nature Cell Biology·Erich A Nigg, Tim Stearns
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nobutoshi TanakaMasatoshi Takeichi
Apr 11, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark A ZanderFreda D Miller
Jul 9, 2014·Annual Review of Cell and Developmental Biology·Elena TavernaWieland B Huttner
Oct 6, 2014·Nature Neuroscience·Ryan InsoleraSong-Hai Shi
Apr 29, 2015·The EMBO Journal·Camino de Juan RomeroVíctor Borrell
Jul 15, 2015·The EMBO Journal·Sanjeeb Kumar SahuVijay K Tiwari
Jul 24, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chao ChenMaria J Donoghue
Sep 1, 2015·Nature Cell Biology·Sabine Petry, Ronald D Vale
Apr 9, 2016·The EMBO Journal·Virginia FernándezVíctor Borrell
Jun 7, 2016·Nature Communications·Maria Ángeles Martínez-MartínezVíctor Borrell
Jul 27, 2018·Open Biology·Rustem Uzbekov, Irina Alieva
Oct 5, 2018·Journal of Cell Science·Varisa PongrakhananonPithi Chanvorachote

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Citations

Jan 12, 2020·Cytoskeleton·Durga Praveen MekaFroylan Calderon de Anda
Nov 16, 2019·Nature Communications·Victor V ChizhikovKathleen J Millen
Nov 5, 2019·F1000Research·Victor Borrell
May 6, 2020·Human Genetics·Hanan E ShamseldinFowzan S Alkuraya
May 17, 2019·ELife·Achira RoyKathleen J Millen
Sep 2, 2020·Nature Communications·Zsófia I LászlóIstván Katona
Feb 2, 2021·Frontiers in Cellular Neuroscience·Cedric Bressan, Armen Saghatelyan
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Ayano Kawaguchi
Dec 7, 2020·Current Opinion in Structural Biology·Cayetano Gonzalez
Dec 19, 2020·Current Opinion in Structural Biology·Michel Bornens
Dec 5, 2020·Current Opinion in Neurobiology·Gonzalo Ortiz-Álvarez, Nathalie Spassky
Oct 24, 2020·Current Opinion in Neurobiology·Fiona Francis, Silvia Cappello
May 22, 2021·The Journal of Cell Biology·Laure CoquandAlexandre D Baffet
Jun 24, 2021·Journal of the American Chemical Society·Yiheng DaiHuaping Xu
Aug 2, 2021·Current Opinion in Genetics & Development·Sven FalkMarisa Karow
Jul 25, 2021·Current Opinion in Neurobiology·Jiajun YangSong-Hai Shi
Aug 17, 2021·Biochemical Society Transactions·Lei XingWieland B Huttner
Jul 16, 2021·Journal of Molecular Cell Biology·Feifei Qi, Jun Zhou
Oct 12, 2021·Physiological Reviews·Lucia Del-Valle-Anton, Víctor Borrell

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Methods Mentioned

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delamination

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