The cerebellum linearly encodes whisker position during voluntary movement

ELife
Susu ChenPaul Chadderton

Abstract

Active whisking is an important model sensorimotor behavior, but the function of the cerebellum in the rodent whisker system is unknown. We have made patch clamp recordings from Purkinje cells in vivo to identify whether cerebellar output encodes kinematic features of whisking including the phase and set point. We show that Purkinje cell spiking activity changes strongly during whisking bouts. On average, the changes in simple spike rate coincide with or slightly precede movement, indicating that the synaptic drive responsible for these changes is predominantly of efferent (motor) rather than re-afferent (sensory) origin. Remarkably, on-going changes in simple spike rate provide an accurate linear read-out of whisker set point. Thus, despite receiving several hundred thousand discrete synaptic inputs across a non-linear dendritic tree, Purkinje cells integrate parallel fiber input to generate precise information about whisking kinematics through linear changes in firing rate.

References

Jan 1, 1990·Somatosensory & Motor Research·S H LichtensteinD J Simons
Jun 1, 1969·The Journal of Physiology·D Marr
Jan 1, 1982·Biological cybernetics·M Fujita
Nov 1, 1995·Journal of Neurophysiology·C I De ZeeuwJ I Simpson
Jan 1, 1996·Somatosensory & Motor Research·G E CarvellD J Simons
Aug 17, 1999·Somatosensory & Motor Research·D KleinfeldS M O'Connor
Feb 13, 2003·Annals of the New York Academy of Sciences·Neal H Barmack, Vadim Yakhnitsa
Apr 23, 2004·Nature·Paul ChaddertonMichael Häusser
Aug 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Karunesh Ganguly, David Kleinfeld
Jan 25, 2005·Nature Neuroscience·Yonatan LoewensteinMichael Häusser
Apr 12, 2006·PLoS Biology·Chunxiu YuEhud Ahissar
Jul 14, 2006·Current Opinion in Neurobiology·David KleinfeldMathew E Diamond
Dec 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joy T Walter, Kamran Khodakhah
Mar 21, 2008·Journal of Neurophysiology·Lucas J Herfst, Michael Brecht
Jul 22, 2008·Nature Reviews. Neuroscience·Mathew E DiamondEhud Ahissar
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joy T Walter, Kamran Khodakhah
Mar 10, 2009·Nature Neuroscience·John C Curtis, David Kleinfeld
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hana RosDavid A McCormick
Dec 8, 2009·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·P KohlerL Wallman
Aug 21, 2010·The Journal of Physiology·Laurens W J BosmanChris I De Zeeuw
Nov 27, 2010·Science·Ferenc MatyasCarl C H Petersen
Sep 1, 1998·Trends in Cognitive Sciences·D M WolpertM Kawato
Mar 26, 2011·Neuron·Sylvain CrochetCarl C H Petersen
May 6, 2011·Nature Reviews. Neuroscience·Chris I De ZeeuwSebastiaan K Koekkoek
Nov 9, 2011·Frontiers in Integrative Neuroscience·Laurens W J BosmanChris I De Zeeuw
Dec 27, 2011·Nature·Abigail L Person, Indira M Raman
Feb 3, 2012·Journal of Neurophysiology·Sung-min ParkKamran Khodakhah
Jul 14, 2012·PLoS Computational Biology·Nathan G ClackEugene W Myers

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Citations

Jul 6, 2016·Frontiers in Human Neuroscience·Anne GierschPhilippe Isope
Aug 10, 2016·Current Opinion in Neurobiology·Richard Warren, Nathaniel B Sawtell
Jul 10, 2018·Annual Review of Neuroscience·Jennifer L Raymond, Javier F Medina
Mar 17, 2018·Nature Communications·Martha L StrengTimothy J Ebner
Aug 11, 2017·Nature Communications·Susu ChenPaul Chadderton
Jul 14, 2017·Journal of Neurophysiology·Martha L StrengTimothy J Ebner
Jan 11, 2019·The Cerebellum·Hirokazu TanakaShinji Kakei
Jun 4, 2019·Frontiers in Computational Neuroscience·Lingling AnJian K Liu
Dec 14, 2018·Frontiers in Neural Circuits·Miki KaneshigeTakahiro Furuta
Oct 2, 2019·Frontiers in Systems Neuroscience·Yunliang Zang, Erik De Schutter
Nov 19, 2020·Nature Reviews. Neuroscience·Chris I De Zeeuw
Jun 26, 2021·Nature Neuroscience·Frederic LanoreR Angus Silver
Jun 9, 2019·Neuron·Matthew I Becker, Abigail L Person

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