Our vision of the cerebellum has been gradually transformed throughout the last century from a 'little brain' to a 'neuronal machine' capable of multitasks, all arguably based on a principle computational model. We review here the main functions of the cerebellum in light of its organization and connectivity. In addition to providing a clear and extensive review of the cerebellar literature, we emphasize the role of the cerebellum in nociception, which is novel to the neurophysiology of pain. However, it is premature to conclude that the cerebellum influences sensory experience in the absence of clinical data.
The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. III. The projection to the vermal visual area
A comparative study of the neurons of origin of the spinocerebellar afferents in the rat, cat and squirrel monkey based on the retrograde transport of horseradish peroxidase
Proximal limb movements in response to microstimulation of primate dentate and interpositus nuclei mediated by brain-stem structures
Fractured somatotopy in granule cell tactile areas of rat cerebellar hemispheres revealed by micromapping
The pontine projection to the cerebellar vermal visual area studied by means of the retrograde axonal transport of horseradish peroxidase
The ventral spino-olivocerebellar system in the cat. III. Functional characteristics of the five paths
The postsynaptic dorsal column pathway mediates cutaneous nociceptive information to cerebellar climbing fibres in the cat
Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
Visual pathways to the cerebellum: segregation in the pontine nuclei of terminal fields from different visual cortical areas in the cat
Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat
Stimulation of cat cutaneous nociceptive C fibres causing tonic and synchronous activity in climbing fibres
Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report
Corticopontine projection in the macaque: the distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei
Dynamic single unit simulation of a realistic cerebellar network model. II. Purkinje cell activity within the basic circuit and modified by inhibitory systems
Electron microscopic observations on the spinal projections to the cerebellar nuclei in the cat and rabbit
Effect upon eye movements of rabbits induced by severance of mossy fiber visual pathway to the cerebellar flocculus
Surgical interruption of a midline dorsal column visceral pain pathway. Case report and review of the literature
Characterization of neurons in the area of the medullary lateral reticular nucleus responsive to noxious visceral and cutaneous stimuli
Spatial organization of proprioception in the cat spinocerebellum. Purkinje cell responses to passive foot rotation
Modification of activity-dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex
Cerebellar output exerts spatially organized influence on neural responses in the rat superior colliculus
Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis
The cerebellum is necessary for rabbit classical eyeblink conditioning with a non-somatosensory (photic) unconditioned stimulus
Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms
Uncrossed and crossed projections from the upper cervical spinal cord to the cerebellar nuclei in the rat, studied by anterograde axonal tracing
Cooperation of the basal ganglia, cerebellum, sensory cerebrum and hippocampus: possible implications for cognition, consciousness, intelligence and creativity
Stimulation in the rat fastigial nucleus enhances the responses of neurons in the dorsal column nuclei to innocuous stimuli
Brain afferents to the medullary dorsal reticular nucleus: a retrograde and anterograde tracing study in the rat
Functional localization in the cerebellum. I. Organization in longitudinal cortico-nuclear zones and their contribution to the control of posture, both extrapyramidal and pyramidal
Sensory acquisition in the cerebellum: an FMRI study of cerebrocerebellar interaction during visual duration discrimination
Contributions of the cerebellum to disturbed central processing of visceral stimuli in irritable bowel syndrome
Localization of CGRP receptor components, CGRP, and receptor binding sites in human and rhesus cerebellar cortex
Discrete changes in cortical activation during experimentally induced referred muscle pain: a single-trial fMRI study
Basolateral amygdala inactivation impairs learning-induced long-term potentiation in the cerebellar cortex
Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease
Temporal filtering of nociceptive information by dynamic activation of endogenous pain modulatory systems
Connectivity of the human pedunculopontine nucleus region and diffusion tensor imaging in surgical targeting
Disrupted cerebellar development in preterm infants is associated with impaired neurodevelopmental outcome
Influence of intramuscular heat stimulation on modulation of nociception: complex role of central opioid receptors in descending facilitation and inhibition
Differential input to dorsal horn dorsal spinocerebellar tract neurons in mid- and low-lumbar segments from upper cervical spinal cord in the cat
Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study
Functional magnetic resonance imaging of cerebral activation during spinal cord stimulation in failed back surgery syndrome patients
Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study
Significant differences in central imaging of histamine-induced itch between atopic dermatitis and healthy subjects
Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: a resting-state fMRI study
Altered hypothalamic functional connectivity in cluster headache: a longitudinal resting-state functional MRI study
Altered gene expression and functional activity of opioid receptors in the cerebellum of CB1 cannabinoid receptor knockout mice after acute treatments with cannabinoids
The spino-bulbar-cerebellar pathway: Activation of neurons projecting to the lateral reticular nucleus in the rat in response to noxious mechanical stimuli
Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI
A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging
Metabolic plasticity in the supraspinal pain modulating circuitry after noxious stimulus-induced spinal cord LTP
A ¹⁸F-fluorodeoxyglucose MicroPET imaging study to assess changes in brain glucose metabolism in a rat model of surgery-induced latent pain sensitization
Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test
LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration
Pain Experience is Somatotopically Organized and Overlaps with Pain Anticipation in the Human Cerebellum
Involvement of post-translational modification of neuronal plasticity-related proteins in hyperalgesia revealed by a proteomic analysis
Inhibition of spinal cord dorsal horn neuronal activity by electrical stimulation of the cerebellar cortex
Role for human posterior parietal cortex in visual processing of aversive objects in peripersonal space
The Role of the Cerebellum in Pain Perception: A Brain SPECT Perfusion Study in Patients with Burn Injuries.
Different Degree Centrality Changes in the Brain after Acupuncture on Contralateral or Ipsilateral Acupoint in Patients with Chronic Shoulder Pain: A Resting-State fMRI Study.
Differential expression of cerebellar metabotropic glutamate receptors mGLUR2/3 and mGLUR4a after the administration of a convulsant drug and the adenosine analogue cyclopentyladenosine
Galvanic Vestibular Stimulation (GVS) Augments Deficient Pedunculopontine Nucleus (PPN) Connectivity in Mild Parkinson's Disease: fMRI Effects of Different Stimuli
TRPV1 Responses in the Cerebellum Lobules V, VIa and VII Using Electroacupuncture Treatment for Inflammatory Hyperalgesia in Murine Model.
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