The Cerebral Hemodynamic Response to Pain in Preterm Infants With Fetal Growth Restriction

Frontiers in Pediatrics
Laura M L DixFlora Y Wong

Abstract

Background: Preterm infants undergoing intensive care often experience painful procedures such as heel lance for blood sampling. Knowledge of the cerebral hemodynamic response to painful stimuli contributes to understanding of cortical pain processing and the neurovascular network in the preterm brain. Previous research has demonstrated cerebral hemodynamic responses using near-infrared spectroscopy (NIRS) after noxious stimuli in infants appropriately grown for age (AGA). But this has not been studied in infants born small for gestational age after fetal growth restriction (FGR). FGR infants differ in brain development due to utero-placental insufficiency leading to the intrauterine growth restriction, and cerebral response to pain may be altered. Objectives: We aimed to compare the cerebral hemodynamic response to painful stimuli (heel lance) in FGR and AGA infants. Methods: Preterm FGR infants (n = 20) and AGA infants (n = 15) born at 28-32 weeks' gestation were studied at mean ± SD postnatal age of 11.5 ± 2.4 and 10.5 ± 2.4 days, respectively. Infants had baseline echocardiographic assessment of ductus arteriosus and stroke volume. They were monitored with NIRS for changes in tissue oxygenation index (TOI, %), and oxygenate...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·T JahnbergJ Martinson
Oct 1, 1991·Radiology·F P HadlockJ Martinez-Poyer
Nov 1, 1986·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F van BelJ H Ruys
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D A BenaronD K Stevenson
Aug 23, 2005·NeuroImage·Stephan G ErberichFloyd Gilles
Mar 15, 2006·Pain·Marco BartocciK J S Anand
Apr 7, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebeccah SlaterMaria Fitzgerald
Jun 27, 2008·PLoS Medicine·Rebeccah SlaterMaria Fitzgerald
Jul 3, 2008·JAMA : the Journal of the American Medical Association·Ricardo CarbajalGérard Bréart
Jul 11, 2012·NeuroImage·Tomoki ArichiA David Edwards
Feb 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mariel G KozbergElizabeth M C Hillman
Jul 28, 2013·Fetal Diagnosis and Therapy·Ahmet A Baschat
Feb 3, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Margie Castillo-MelendezSuzanne L Miller
Jun 27, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M Pérez-CruzE Gratacós
Aug 28, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Emily CohenFrank van Bel
Nov 27, 2015·The Journal of Physiology·Suzanne L MillerCarina Mallard
Apr 19, 2016·International Journal of Clinical Pharmacology and Therapeutics·Karel Allegaert, John N van den Anker
Jul 1, 2017·The Journal of Pediatrics·Arvind SehgalGraeme R Polglase
Oct 10, 2018·The Journal of Pediatrics·Kelsee L ShepherdFlora Y Wong

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