PMID: 7539946Apr 1, 1995Paper

The cerebral neurons of Helix aspersa during hibernation. Changes in the cytochemical detection of calmodulin, cytoskeletal components and phosphatases

Tissue & Cell
C VignolaG Bernocchi

Abstract

Some markers of the intracellular systems that regulate neuronal activity and morphology were analyzed in the cerebral ganglion of hibernating snails (Helix aspersa), in comparison with active animals. The immunocytochemical expression of a calcium-binding protein, i.e. calmodulin, and some cytoskeletal components, i.e. 200 kDa phosphorylated neurofilament protein (pNFH), microtubule associated protein 2 (MAP2) and alpha-tubulin were analyzed by the use of a panel of antibodies raised against mammal antigens. Moreover, by enzymatic reactions the Ca(2+)-ATPase and alkaline phosphatase (AIPase) activities were demonstrated. In comparison with the active phase, the hibernation induced an increase in the immunopositivity for calmodulin in all the neurons. The increase may be linked to unmasking of immunoreactive epitopes due to conformational changes of the protein, which in turn may be a consequence of a reduction or absence of binding with calcium ions or of a real increase in the amount of calmodulin in the somata of neurons. In any event, both the hypotheses indicate that neurons have decreased or suppressed the Ca(2+)-dependent mechanisms as also shown by the lower Ca(2+)-ATPase activity. Nevertheless, the AIPase activity, whi...Continue Reading

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Citations

Oct 19, 2010·Cell and Tissue Research·Tamás RószerGáspár Bánfalvi
Mar 31, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Eliane BorgesRenato Dutra Dias
May 16, 2019·International Journal of Molecular Sciences·Giacomo Gattoni, Graziella Bernocchi
Aug 27, 2021·Metabolites·Alexander Myrka, Leslie Buck

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