The CF-Sputum Induction Trial (CF-SpIT) to assess lower airway bacterial sampling in young children with cystic fibrosis: a prospective internally controlled interventional trial

The Lancet. Respiratory Medicine
Katherine RonchettiJulian Forton

Abstract

Pathogen surveillance is challenging but crucial in children with cystic fibrosis-who are often non-productive of sputum even if actively coughing-because infection and lung disease begin early in life. The role of sputum induction as a diagnostic tool for infection has not previously been systematically addressed in young children with cystic fibrosis. We aimed to assess the pathogen yield from sputum induction compared with that from cough swab and single-lobe, two-lobe, and six-lobe bronchoalveolar lavage. This prospective internally controlled interventional trial was done at the Children's Hospital for Wales (Cardiff, UK) in children with cystic fibrosis aged between 6 months and 18 years. Samples from cough swab, sputum induction, and single-lobe, two-lobe, and six-lobe bronchoalveolar lavage were matched for within-patient comparisons. Primary outcomes were comparative pathogen yield between sputum induction and cough swab for stage 1, and between sputum induction, and single-lobe, two-lobe, and six-lobe bronchoalveolar lavage for stage 2. Data were analysed as per protocol. This study is registered with the UK Clinical Research Network (14615) and with the International Standard Randomised Controlled Trial Network Regis...Continue Reading

Citations

Aug 17, 2018·Current Opinion in Pulmonary Medicine·Matthew N Hurley, Alan R Smyth
May 21, 2019·Pediatric Pulmonology·Adrienne P Savant, Susanna A McColley
Aug 10, 2019·Current Opinion in Pulmonary Medicine·Edith T Zemanick, Scott C Bell
Dec 11, 2019·Pediatric Pulmonology·Stacey L MartinianoLindsay J Caverly
Dec 18, 2019·The Cochrane Database of Systematic Reviews·Sally PalserAlan R Smyth
Nov 27, 2019·American Journal of Respiratory and Critical Care Medicine·Andrew TurnbullJane Davies
May 15, 2020·Genes·Alice Françoise, Geneviève Héry-Arnaud
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Oct 2, 2020·Scientific Reports·Sudha BhadrirajuJohn Z Metcalfe
Sep 19, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·G TaccettiI Sermet-Gaudelus
Nov 11, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Rosemary CarzinoUNKNOWN AREST CF
Aug 5, 2020·American Journal of Respiratory and Critical Care Medicine·Anthony J FischerDominique H Limoli
Jan 16, 2021·Breathe·George FereosCara J Bossley
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Nov 7, 2021·Archives of Disease in Childhood·Gemma L SaintUNKNOWN NTM Collaborators Group

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Methods Mentioned

BETA
bronchoalveolar lavage
bronchoalveolar
lavage
RISA

Software Mentioned

SPSS
Cf
SpIT

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