The cGMP signaling pathway affects feeding behavior in the necromenic nematode Pristionchus pacificus.

PloS One
Silvina M KroetzRay L Hong

Abstract

The genetic tractability and the species-specific association with beetles make the nematode Pristionchus pacificus an exciting emerging model organism for comparative studies in development and behavior. P. pacificus differs from Caenorhabditis elegans (a bacterial feeder) by its buccal teeth and the lack of pharyngeal grinders, but almost nothing is known about which genes coordinate P. pacificus feeding behaviors, such as pharyngeal pumping rate, locomotion, and fat storage. We analyzed P. pacificus pharyngeal pumping rate and locomotion behavior on and off food, as well as on different species of bacteria (Escherichia coli, Bacillus subtilis, and Caulobacter crescentus). We found that the cGMP-dependent protein kinase G (PKG) Ppa-EGL-4 in P. pacificus plays an important role in regulating the pumping rate, mouth form dimorphism, the duration of forward locomotion, and the amount of fat stored in intestine. In addition, Ppa-EGL-4 interacts with Ppa-OBI-1, a recently identified protein involved in chemosensation, to influence feeding and locomotion behavior. We also found that C. crescentus NA1000 increased pharyngeal pumping as well as fat storage in P. pacificus. The PKG EGL-4 has conserved functions in regulating feeding b...Continue Reading

References

Jul 1, 1975·Journal of Bacteriology·M G Sargent
Mar 1, 1990·The Journal of Experimental Zoology·L Avery, H R Horvitz
Apr 27, 2002·Science·Y Ben-ShaharG E Robinson
Jun 11, 2003·The Journal of Experimental Biology·Leon Avery, Boris B Shtonda
Aug 28, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yoshiya NakanoYasumi Ohshima
Feb 9, 2005·BMC Genetics·Christopher J CroninPaul W Sternberg
Dec 16, 2005·The Journal of Experimental Biology·Boris Borisovich Shtonda, Leon Avery
Apr 18, 2006·Zoology : Analysis of Complex Systems, ZACS·Matthias HerrmannRalf J Sommer
May 16, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ray L Hong, Ralf J Sommer
Jun 9, 2006·Journal of Theoretical Biology·Jan KarbowskiPaul W Sternberg
May 8, 2008·Evolution & Development·Ray L HongRalf J Sommer
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ray L HongRalf J Sommer
Jun 3, 2008·The Journal of Experimental Biology·Robbie RaeRalf J Sommer
Oct 22, 2009·PloS One·Kyleann K BrooksJennifer L Watts
Nov 4, 2009·Cell Metabolism·Eyleen J O'RourkeGary Ruvkun
Mar 1, 1946·Journal of Bacteriology·J W FOSTER, H B WOODRUFF
Nov 26, 2010·Current Biology : CB·Marie-Anne Félix, Christian Braendle
Feb 1, 2004·Integrative and Comparative Biology·Mark J Fitzpatrick, Marla B Sokolowski

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Citations

Oct 12, 2012·International Journal of Evolutionary Biology·David A Fitzpatrick, Damien M O'Halloran
Nov 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yehuda Ben-Shahar
Sep 6, 2019·Annual Review of Genetics·Ina Anreiter, Marla B Sokolowski
Sep 3, 2016·Journal of Veterinary Science·Masahiro YasudaYukari Date
Oct 30, 2020·Chemosphere·Hendrik FueserWalter Traunspurger
Oct 3, 2014·The Journal of Experimental Biology·Floriane ChardonnetLaure Kaiser
Mar 15, 2015·The Journal of Experimental Biology·Martin WileckiRalf J Sommer

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Methods Mentioned

BETA
X-ray
PCR
genotyping
fluorescence microscopy

Software Mentioned

InStat
Leica LAS
Excel

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