The Challenge of Chamber Stiffness Determination in Chronic Atrial Fibrillation vs. Normal Sinus Rhythm: Echocardiographic Prediction with Simultaneous Hemodynamic Validation

Journal of Atrial Fibrillation
Sina MossahebiSándor J Kovács

Abstract

Echocardiographic diastolic function (DF) assessment remains a challenge in atrial fibrillation (AF), because indexes such as E/A cannot be used and because chronic, rate controlled AF causes chamber remodeling. To determine if echocardiography can accurately characterize diastolic chamber properties we compared 15 chronic AF subjects to 15, age matched normal sinus rhythm (NSR) subjects using simultaneous echocardiography-cardiac catheterization (391 beats analyzed). Conventional DF parameters (DT, Epeak, AT, Edur, E-VTI, E/E') and validated, E-wave derived, kinematic modeling based chamber stiffness parameter (k), were compared. For validation, chamber stiffness (dP/dV) was independently determined from simultaneous, multi-beat P-V loop data. Results show that neither AT, Epeak nor E-VTI differentiated between groups. Although DT, Edur and E/E' did differentiate between groups (DTNSR vs. DTAF p < 0.001, EdurNSR vs. EdurAF p < 0.001, E/E'NSR vs. E/E'AF p < 0.05), the model derived chamber stiffness parameter k was the only parameter specific for chamber stiffness, (kNSR vs. kAF p <0.005). The invasive gold standard determined end-diastolic stiffness in NSR was indistinguishable from end-diastolic (i.e. diastatic) stiffness in ...Continue Reading

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