PMID: 9192483Mar 1, 1997Paper

The challenge of endomyocardial biopsy interpretation in assessing cardiac allograft rejection

Current Opinion in Cardiology
Gayle L Winters

Abstract

The endomyocardial biopsy has long been the preferred technique for monitoring the rejection status of the cardiac allograft. During the past year, published reports have addressed important issues concerning the endomyocardial biopsy, including the reliability of the International Society for Heart and Lung Transplantation grading system; problem areas in posttransplantation biopsy interpretation, including grade 2 rejection and myocyte injury, Quilty lesions, and ischemic injury; the natural history of grade 2 rejection; the necessity of surveillance biopsies late in the posttransplantation course; and the efficacy of numerous noninvasive techniques in diagnosing or predicting rejection. No technique developed to date has been shown to have the sensitivity or specificity needed to replace the endomyocardial biopsy as a diagnostic tool. In addition, studies of endomyocardial biopsy specimens have furthered our understanding of the pathobiology of rejection and other transplant-related conditions.

Citations

Aug 12, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Diana M PlazaLuis F García
Dec 16, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael DandelRoland Hetzer
Jun 1, 2012·Surgical Pathology Clinics·Gayle L Winters
Aug 6, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Annalisa AngeliniMargaret Burke
Jul 21, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Rosa CostanzoUNKNOWN International Society of Heart and Lung Transplantation Guidelines
Dec 6, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ornella LeoneGayle L Winters
Feb 1, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Przemysław PalkaDarryl J Burstow
Jan 25, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Brendan J KeatingBrian D Piening
Jul 10, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M H KownR C Robbins
Apr 10, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Nupoor A GajjarMichael C Fishbein

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