The challenge of real-time measurements of nitric oxide release in the brain

Autonomic Neuroscience : Basic & Clinical
S WangS Kasparov

Abstract

Nitric oxide (NO) acts as a signalling molecule in the brain. NO has been implicated in a variety of central functions such as learning, plasticity and neurodegeneration. It is also involved in regulation of autonomic homeostasis at different levels of neuraxis including the nucleus tractus solitarii. In spite of the ample evidence for NO-mediated signalling many aspects of its mechanism of action the brain remain unknown largely due to the difficulties of NO detection in real time coupled with its unique ability to freely cross cellular membranes. Here we give a brief overview of the currently available options for NO detection in the brain (such as electrochemistry, fluorescent indicators, electron-paramagnetic resonance) and consider some of their limitations. We conclude that it would be extremely useful to develop a highly sensitive probe for NO detection with some kind of build-in amplification which would magnify the changes triggered by NO to allow its detection within microdomains of the brain tissue in real time.

References

Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Oct 1, 1988·Hypertension·S MoncadaE A Higgs
Sep 23, 1994·Cell·H H Schmidt, U Walter
May 1, 1996·Clinical Pharmacokinetics·B RosenkranzM J Parnham
Jan 1, 1996·Progress in Neurobiology·A J Lawrence, B Jarrott
May 1, 1997·Journal of Vascular Research·C M Boulanger, P M Vanhoutte
Aug 25, 1997·The Journal of Comparative Neurology·T L KrukoffJ H Jhamandas
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·T L Krukoff
Dec 14, 1999·Journal of Neuroscience Methods·L A BrownT A Lovick
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·L L PearceE S Levitan
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·T C BellamyJ Garthwaite
Nov 14, 2000·The Journal of Biological Chemistry·T C Bellamy, J Garthwaite
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·A HondaW R Dostmann
Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
Nov 3, 2001·The Journal of Physiology·C Griffiths, J Garthwaite
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A J KanaiJ Peterson
Mar 6, 2002·British Journal of Pharmacology·Juan V Esplugues
Oct 9, 2002·The Biochemical Journal·Robert G KeynesJohn Garthwaite
Nov 26, 2002·Trends in Neurosciences·Julian F R PatonDavid J Paterson
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Jorge A CarvajalCarl P Weiner
Jul 26, 2003·Circulation Research·Andreas Friebe, Doris Koesling
Sep 11, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·J C Millar
Mar 5, 2004·Nitric Oxide : Biology and Chemistry·Oliver von Bohlen und Halbach
Mar 16, 2004·The European Journal of Neuroscience·Robert G KeynesJohn Garthwaite
Mar 17, 2004·British Journal of Pharmacology·Victoria Wykes, John Garthwaite
May 26, 2004·Nitric Oxide : Biology and Chemistry·Rachel WeitzdoerferBarbara Lubec
Jan 5, 2005·Free Radical Biology & Medicine·Juan RodriguezMartin Feelisch
Apr 6, 2005·Trends in Pharmacological Sciences·Pedram Ghafourifar, Enrique Cadenas

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Citations

Jul 1, 2008·The European Journal of Neuroscience·John Garthwaite
Mar 28, 2008·The Analyst·Xiaoying YeJonathan V Sweedler
Jan 3, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Francisco GalindoDavid A Russell
Dec 24, 2018·American Journal of Physical Anthropology·Tyler Hill, John D Polk

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