The challenges and the promise of molecular targeted therapy in malignant gliomas

Neoplasia : an International Journal for Oncology Research
Hongxiang WangJuxiang Chen

Abstract

Malignant gliomas are the most common malignant primary brain tumors and one of the most challenging forms of cancers to treat. Despite advances in conventional treatment, the outcome for patients remains almost universally fatal. This poor prognosis is due to therapeutic resistance and tumor recurrence after surgical removal. However, over the past decade, molecular targeted therapy has held the promise of transforming the care of malignant glioma patients. Significant progress in understanding the molecular pathology of gliomagenesis and maintenance of the malignant phenotypes will open opportunities to rationally develop new molecular targeted therapy options. Recently, therapeutic strategies have focused on targeting pro-growth signaling mediated by receptor tyrosine kinase/RAS/phosphatidylinositol 3-kinase pathway, proangiogenic pathways, and several other vital intracellular signaling networks, such as proteasome and histone deacetylase. However, several factors such as cross-talk between the altered pathways, intratumoral molecular heterogeneity, and therapeutic resistance of glioma stem cells (GSCs) have limited the activity of single agents. Efforts are ongoing to study in depth the complex molecular biology of glioma,...Continue Reading

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Methods Mentioned

BETA
surgical resection
xenograft
xenografts
acetylation

Clinical Trials Mentioned

NCT00813943
NCT00727506
NCT00977431
NCT00423735
NCT00379080
NCT00731731
NCT01378481
NCT00302159
NCT01051557
NCT01269411

Related Concepts

Metazoa
Antineoplastic Agents
Brain Tumor, Recurrent
Combined Modality Therapy
Mixed Gliomas
Signal Transduction
Molecular Targeted Therapy
Biological Markers
Brain Neoplasms
Malignant Neoplasms

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