The challenges of diagnosing diabetes in childhood.

Diagnosis
Mairi PucciGiuseppe Lippi

Abstract

Diabetes is one of the most prevalent diseases worldwide, whereby type 1 diabetes mellitus (T1DM) alone involves nearly 15 million patients. Although T1DM and type 2 diabetes mellitus (T2DM) are the most common types, there are other forms of diabetes which may remain often under-diagnosed, or that can be misdiagnosed as being T1DM or T2DM. After an initial diagnostic step, the differential diagnosis among T1DM, T2DM, Maturity-Onset Diabetes of the Young (MODY) and others forms has important implication for both therapeutic and behavioral decisions. Although the criteria used for diagnosing diabetes mellitus are well defined by the guidelines of the American Diabetes Association (ADA), no clear indications are provided on the optimal approach to be followed for classifying diabetes, especially in children. In this circumstance, both routine and genetic blood test may play a pivotal role. Therefore, the purpose of this article is to provide, through a narrative literature review, some elements that may aid accurate diagnosis and classification of diabetes in children and young people.

References

Jun 3, 2005·The Journal of Clinical Investigation·M Alan PermuttNancy Cox
Sep 14, 2011·Pediatric Diabetes·J LudvigssonU Samuelsson
Apr 2, 2014·Pediatrics·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study Group
May 6, 2014·JAMA : the Journal of the American Medical Association·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study
Jun 13, 2014·Current Diabetes Reports·Elizabeth R Pulgaron, Alan M Delamater
Aug 1, 2014·Annals of Pediatric Endocrinology & Metabolism·Min Jung ChoDae-Yeol Lee
Jan 9, 2015·Medicine·Nita Gandhi Forouhi, Nicholas J Wareham
Jan 13, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ahmet AnıkEce Böber
Jun 27, 2015·Pediatric Diabetes·Ida Margrethe Bach OesterJesper Johannesen
Jan 15, 2016·Clinical Genetics·S A KhanS Khan
Jul 8, 2016·Molecular Syndromology·Evgeny N Suspitsin, Evgeny N Imyanitov
Jan 14, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Karolina Antosik, Maciej Borowiec
Apr 14, 2017·The New England Journal of Medicine·Elizabeth J Mayer-DavisUNKNOWN SEARCH for Diabetes in Youth Study
Aug 15, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Litao QinShixiu Liao
Feb 7, 2018·Clinics in Perinatology·Michelle Blanco LemelmanSiri Atma W Greeley
Feb 28, 2018·Türk Pediatri Arşivi·Birgül KirelNeslihan Tekin
May 20, 2018·Reviews in Endocrine & Metabolic Disorders·Roseanne O YeungMark A Walker
Jun 23, 2018·Current Diabetes Reports·May SanyouraRochelle Naylor
Dec 24, 2018·Advances in Experimental Medicine and Biology·Stephen H TsangTarun Sharma
Jun 28, 2019·European Endocrinology·Elena V VarlamovMaria Fleseriu
Jul 31, 2019·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Tatsuhiko Urakami
Nov 23, 2019·Journal of Clinical Research in Pediatric Endocrinology·Martin Holder, Valerie Schwitzgebel
Dec 4, 2019·Clinical Case Reports·Sejal KadakiaRon S Newfield
Dec 5, 2019·Wiener medizinische Wochenschrift·Patrick DinkhauserHarald Hofer
Dec 22, 2019·Diabetes Care·UNKNOWN American Diabetes Association
Jan 29, 2020·Journal of Clinical Research in Pediatric Endocrinology·Aashish SethiSenthil Senniappan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved