The challenges of lupus anticoagulants

Expert Review of Hematology
Cecilia Beatrice ChighizolaPier Luigi Meroni

Abstract

The term "lupus anticoagulant" (LA) refers to a heterogeneous group of immunoglobulins behaving as acquired in vitro inhibitors of coagulation. These antibodies, namely anti-β2GPI and anti-prothrombin antibodies, induce the in vitro elongation of clotting time interfering with phospholipid-dependent coagulation cofactors. Positive LA is associated with thrombosis and pregnancy complications, providing one of the three laboratory criteria for the classification of the anti-phospholipid syndrome. LA is the strongest predictor of clinical events, especially when associated with other anti-phospholipid antibodies. Much more controversial is the risk conveyed by isolated and weak LA. LA detection is technically laborious, envisaging screening, mixing and confirming tests. Hopefully critical issues in LA detection, such as the interference of anticoagulants, will be overcome, in the next future.

References

Sep 2, 2000·Journal of Autoimmunity·T Exner
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·M J A SimmelinkR H W M Derksen
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·M J A SimmelinkP G De Groot
Apr 3, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Gary W Moore, Geoffrey F Savidge
Apr 22, 2004·Journal of Thrombosis and Haemostasis : JTH·V PengoS Iliceto
Jul 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Edouard M BeversGeorge M Willems
Jun 11, 2005·Journal of Thrombosis and Haemostasis : JTH·R ForastieroL Aversa
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·P G de GrootF R Rosendaal
Apr 28, 2007·Journal of Thrombosis and Haemostasis : JTH·V PengoUNKNOWN Participating Centres of Italian Federation of Thrombosis Centres (FCSA)
Nov 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Vittorio PengoArmando Tripodi
Jul 25, 2009·Journal of Thrombosis and Haemostasis : JTH·V PengoUNKNOWN Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the Interna
Aug 1, 2009·Arthritis and Rheumatism·Yoshie SakaiTakao Koike
Oct 31, 2009·Journal of Thrombosis and Haemostasis : JTH·V PengoS Iliceto
Jun 15, 2010·Thrombosis Research·V PengoUNKNOWN Italian Federation of Thrombosis Centers (FCSA)
Jan 25, 2011·Journal of Thrombosis and Haemostasis : JTH·I Dienava-VerdooldB de Laat
Jun 15, 2011·Journal of Thrombosis and Haemostasis : JTH·G M A van OsPh G de Groot
Jul 20, 2011·Leukemia & Lymphoma·Klaus LechnerIngrid Pabinger
Feb 9, 2012·British Journal of Haematology·David KeelingUNKNOWN British Committee for Standards in Haematology
May 11, 2012·Seminars in Thrombosis and Hemostasis·Geoffrey KershawYun-Mi Nguy
May 29, 2012·Lupus·G Reber, P Meijer
Apr 11, 2013·Immunologic Research·Francesca PregnolatoPier Luigi Meroni
Apr 23, 2013·Journal of Thrombosis and Haemostasis : JTH·V PengoS Padayattil Jose
Jan 7, 2014·Current Rheumatology Reports·Cecilia Beatrice ChighizolaPier Luigi Meroni
Feb 6, 2014·Seminars in Thrombosis and Hemostasis·Kristi J SmockElizabeth M Van Cott
Apr 23, 2014·International Journal of Laboratory Hematology·K M J Devreese
Apr 23, 2014·International Journal of Laboratory Hematology·G W Moore
Jul 11, 2014·Thrombosis and Haemostasis·Maarten T T PenningsRolf T Urbanus
Nov 13, 2014·Seminars in Thrombosis and Hemostasis·Vittorio PengoAlessandra Banzato
Dec 3, 2014·Thrombosis Research·Vittorio PengoAmelia Ruffatti

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Citations

Feb 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marisa BenagianoMario M D'Elios
Jul 5, 2018·Frontiers in Immunology·Francesco TedescoPier Luigi Meroni
Jul 16, 2019·American Journal of Clinical Pathology·Nahla HeikalAnne E Tebo
Feb 13, 2019·Current Opinion in Rheumatology·Andrew P VreedeJason S Knight
Jan 30, 2021·Current Rheumatology Reports·Silvia RosinaRolando Cimaz
Feb 27, 2021·Medicina clínica·Jaume Alijotas-Reig

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