The challenges of vitamin and mineral supplementation in children with inherited metabolic disorders: a prospective trial

Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
Anne DalyAnita MacDonald

Abstract

In order to achieve metabolic stability, dietary treatment of inborn errors of metabolism may require restriction of protein, fat or carbohydrate. Manipulation of dietary intake potentially reduces micronutrient status, and provision of a comprehensive vitamin and mineral supplement becomes an essential adjunct to dietary treatment. To review the efficacy of a new complete vitamin and mineral supplement [Fruitivits, Vitaflo Ltd] in 14 subjects in an open prospective 26-week study. All subjects had dietary restrictions: low protein diets (57%, n = 8), regular daytime cornstarch and overnight glucose polymer tube feeds (29%, n = 4), low fat diet (7%, n = 1) and modified Atkins diet (7%, n = 1). Plasma nutritional biochemistry, anthropometry and food frequency questionnaires were collected at week 0, 12 and 26 weeks respectively. Five nutritional parameters showed a significant improvement from baseline (week 0) to study end (week 26): folate (P = 0.01), vitamin E (P = 0.04), plasma selenium (P = 0.002), whole blood selenium (P = 0.04) and total vitamin D (P = 0.008). All the other nutritional markers did not significantly change. Even with regular monitoring, 37% of the product remained unused. Despite improvements in some nutrit...Continue Reading

References

Oct 13, 1999·Journal of Inherited Metabolic Disease·P S KishnaniY T Chen
Feb 28, 2002·Archives of Disease in Childhood·N J Shaw, B R Pal
Oct 23, 2008·Journal of Inherited Metabolic Disease·A MacDonaldA Chakrapani
May 8, 2009·The American Journal of Clinical Nutrition·Nicola M LoweTamás Decsi
Sep 12, 2009·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·H Gokmen-OzelA Chakrapani
Feb 11, 2012·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S EvansA Macdonald
Mar 20, 2012·The Journal of Pediatrics·Thatjana GardeitchikAvihu Boneh
Jul 3, 2013·Journal of Pediatric Psychology·Rachel Neff GreenleyJennifer Verrill Schurman
Feb 4, 2014·Annals of Internal Medicine·Gervasio A LamasUNKNOWN TACT (Trial to Assess Chelation Therapy) Investigators

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