PMID: 22553822May 4, 2012Paper

The challenging diagnosis of the rhabdoid carcinoma of the pelvis: a case report with literature review

Applied Immunohistochemistry & Molecular Morphology : AIMM
Maria Rosaria RaspolliniGregor Mikuz

Abstract

Rhabdoid tumor is an uncommon neoplasia characterized by a monotonous population of large, noncohesive cells with vesicular nuclei and large nucleoli. The misleading name was originally suggested because of the striking morphologic resemblance to other skeletal muscle tumors, but neither ultrastructural nor immunohistochemical features support a myogenic origin for this tumor. The rhabdoid tumors of the kidney in pediatric age are characterized by mutation or deletion of 22q11. In adults, tumors with rhabdoid features are uncommon neoplasia reported in different anatomic sites, but their histogenesis is still unclear. We focused on the literature data regarding the rhabdoid features in pelvic and renal tumors, and we describe a carcinoma involving the pelvis and the kidney with exclusive rhabdoid features, which make the anatomical allocation of the tumor difficult. The tumor did not exhibit any similarities to conventional histologic types of renal cell cancer, not even of the sarcomatous type. Tumor cells showed a strong positivity for epithelial markers (AE1/AE3 and CK 8) and for vimentin, whereas they were negative for skeletal and smooth muscle markers. The nuclei of the tumor cells demonstrated a INI1-positive immunohisto...Continue Reading

References

May 1, 1992·The American Journal of Surgical Pathology·S KumarD F Cowan
Jan 1, 1990·The Journal of Urology·W LoweL D True
Jan 1, 1985·Ultrastructural Pathology·M A McNuttA M Vogel
Jun 1, 1996·Genes, Chromosomes & Cancer·J A BiegelC J Bell
May 16, 2000·Advances in Anatomic Pathology·S OginoR W Redline
Oct 7, 2000·The American Journal of Surgical Pathology·N GökdenP A Humphrey
Nov 7, 2001·The Journal of Urology·M DuvdevaniY Mor
Nov 26, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·W G McCluggage
Dec 4, 2002·Histopathology·K KuroiwaM Tsuneyoshi
Jan 24, 2006·Human Pathology·Anil V ParwaniJonathan I Epstein
Feb 14, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Delia Perez-MontielSaul Suster
Mar 11, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ellen SigaukeJack Raisanen
Nov 13, 2008·Virchows Archiv : an International Journal of Pathology·Donatella PacchioniGianni Bussolati
Dec 11, 2008·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Anil KapoorSebastien J Hotte
May 13, 2009·Pathology International·Yuki FukumuraTakashi Yao

❮ Previous
Next ❯

Citations

Dec 10, 2015·Virchows Archiv : an International Journal of Pathology·Masaaki SugimotoYoshinao Oda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Surgical Pathology
Maria Delia Perez-MontielSaul Suster
Annals of Coloproctology
Narimantas Evaldas SamalaviciusUgnius Mickys
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
R ChettyD Govender
© 2021 Meta ULC. All rights reserved