The change in circulating galectin-3 predicts absence of atrial fibrillation after thoracoscopic surgical ablation

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Wouter R BergerJoris R de Groot

Abstract

Galectin-3 (Gal-3) is an important mediator of cardiac fibrosis, particularly in heart failure. Increased Gal-3 concentration (Gal-3), associated with increased risk of developing atrial fibrillation (AF), may reflect atrial fibrotic remodelling underlying AF progression. We aimed to investigate whether the change in serum Gal-3 reflects alterations of the arrhythmogenic atrial substrate following thoracoscopic AF surgery, and predicts absence of AF. Consecutive patients undergoing thoracoscopic AF surgery were included. Left atrial appendages (LAAs) and serum were collected during surgery and serum again 6 months thereafter. Gal-3 was determined in tissue and serum. Interstitial collagen in the LAA was quantified using Picrosirius red staining. Ninety-eight patients (76% male, mean age 60 ± 9 years) underwent thoracoscopic surgery for advanced AF. Patients with increased Gal-3 after ablation compared to baseline had a higher recurrence rate compared to patients with decreased or unchanged Gal-3 (HR 2.91, P = 0.014). These patients more frequently had persistent AF, longer AF duration and thick atrial collagen strands (P = 0.049). At baseline, Gal-3 was similar between patients with and without AF recurrence: 14.8 ± 3.9 µg/L vs...Continue Reading

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Citations

Jan 10, 2020·Journal of Clinical Laboratory Analysis·Mengqi GongTong Liu
Oct 5, 2017·Journal of Thrombosis and Thrombolysis·Levent Cerit
Oct 1, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Gokhan AksanKorhan Soylu
Feb 17, 2021·Biomarkers in Medicine·Raffaele SerraGiuseppe F Serraino
Apr 4, 2021·International Journal of Environmental Research and Public Health·Radosław PietrzakBożena Werner

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