The change in circulating galectin-3 predicts absence of atrial fibrillation after thoracoscopic surgical ablation
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Wouter R BergerJoris R de Groot
Abstract
Galectin-3 (Gal-3) is an important mediator of cardiac fibrosis, particularly in heart failure. Increased Gal-3 concentration (Gal-3), associated with increased risk of developing atrial fibrillation (AF), may reflect atrial fibrotic remodelling underlying AF progression. We aimed to investigate whether the change in serum Gal-3 reflects alterations of the arrhythmogenic atrial substrate following thoracoscopic AF surgery, and predicts absence of AF. Consecutive patients undergoing thoracoscopic AF surgery were included. Left atrial appendages (LAAs) and serum were collected during surgery and serum again 6 months thereafter. Gal-3 was determined in tissue and serum. Interstitial collagen in the LAA was quantified using Picrosirius red staining. Ninety-eight patients (76% male, mean age 60 ± 9 years) underwent thoracoscopic surgery for advanced AF. Patients with increased Gal-3 after ablation compared to baseline had a higher recurrence rate compared to patients with decreased or unchanged Gal-3 (HR 2.91, P = 0.014). These patients more frequently had persistent AF, longer AF duration and thick atrial collagen strands (P = 0.049). At baseline, Gal-3 was similar between patients with and without AF recurrence: 14.8 ± 3.9 µg/L vs...Continue Reading
References
Nov 3, 2004·Circulation·Umesh C SharmaYigal M Pinto
Sep 19, 2006·Journal of the American College of Cardiology·Roland R van KimmenadeYigal M Pinto
Oct 27, 2009·The Annals of Thoracic Surgery·James R EdgertonMichael J Mack
Nov 26, 2009·The American Journal of Cardiology·Gerald V NaccarelliKathy L Schulman
Apr 29, 2010·Current Heart Failure Reports·Rudolf A de BoerDirk J van Veldhuisen
Sep 30, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN ESC Committee for Practice Guidelines
Jan 21, 2011·Physiological Reviews·Ulrich SchottenAndreas Goette
May 4, 2011·Cellular Oncology (Dordrecht)·Awal M HadiJeroen A M Beliën
Oct 22, 2011·The Journal of Thoracic and Cardiovascular Surgery·Guillaume S C GeuzebroekRuben Coronel
Nov 1, 2011·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Joris R de GrootJacques M T De Bakker
Mar 3, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hugh CalkinsDavid Wilber
Mar 6, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hugh CalkinsUNKNOWN Heart Rhythm Society Task Force on Catheter and Surgical Ablation of Atrial Fibrillation
Sep 4, 2012·Journal of the American College of Cardiology·Jennifer E HoDaniel Levy
Feb 6, 2014·JAMA : the Journal of the American Medical Association·Nassir F MarroucheJohannes Brachmann
Apr 29, 2014·American Heart Journal·Jennifer E HoEmelia J Benjamin
Jan 22, 2015·The American Journal of Cardiology·Kadri Murat GursesKudret Aytemir
Feb 13, 2015·Circulation. Arrhythmia and Electrophysiology·Sébastien P J KrulJoris R de Groot
Apr 30, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Xiao-Yan WuChang-Sheng Ma
Aug 20, 2015·Circulation. Arrhythmia and Electrophysiology·Salvatore Patanè
Aug 16, 2016·JACC. Basic to Translational Science·Yoshio TakemotoJosé Jalife
Citations
Aug 2, 2018·PloS One·Nicolas ClementyDominique Babuty
Jan 10, 2020·Journal of Clinical Laboratory Analysis·Mengqi GongTong Liu
Oct 5, 2017·Journal of Thrombosis and Thrombolysis·Levent Cerit
Oct 1, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Gokhan AksanKorhan Soylu
Feb 17, 2021·Biomarkers in Medicine·Raffaele SerraGiuseppe F Serraino
Apr 4, 2021·International Journal of Environmental Research and Public Health·Radosław PietrzakBożena Werner
Aug 28, 2021·Biomolecules·Paweł WałekBeata Wożakowska-Kapłon
Jun 10, 2020·Cardiology·Minghan XiaoHua Xiao