The change in ghrelin and obestatin levels in obese children after weight reduction

Acta Paediatrica
Chao Chun ZouZheng Yan Zhao

Abstract

To investigate the role of ghrelin and obestatin in obesity mechanisms. A total of 88 obese children and 25 normal children were enrolled. Moreover, 46 obese children took part in a summer camp for weight reduction. Fasting ghrelin, obestatin and other biochemical parameters were measured in all subjects and re-measured in 45 obese children finishing the camp. The ghrelin levels in the control and obese groups were 67.26 +/- 23.41 pmol/L and 56.53 +/- 15.97 pmol/L with a significant difference (p = 0.039), while the obestatin levels (89.41 +/- 23.63 vs. 83.13 +/- 17.21 pmol/L) were not significantly different (p = 0.083). The ghrelin/obestatin ratio in the controls was significantly higher than that in the obese group (p = 0.014). In the latter, fasting insulin and alanine aminotransferase were independent factors for ghrelin; fasting insulin, weight and gender were independent factors for obestatin and alanine aminotransferase was an independent factor for ghrelin/obestatin. Moreover, ghrelin, obestatin and ghrelin/obestatin increased after weight reduction (p < 0.05, respectively), and the increment in ghrelin and obestatin was associated with a decrement in insulin resistance. These data suggest that ghrelin, obestatin and/o...Continue Reading

References

Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·M PapottiG Muccioli
Oct 27, 2001·Diabetes·A M WrenS R Bloom
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·A M WrenS R Bloom
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Tomomi ShiiyaShigeru Matsukura
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Marco VolanteMauro Papotti
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Nicholas A TritosEleftheria Maratos-Flier
Oct 31, 2003·Molecular and Cellular Biology·Yuxiang SunRoy G Smith
Nov 12, 2003·Experimental Biology and Medicine·Bernard BeckAlain Stricker-Krongrad
Feb 10, 2004·The Journal of Endocrinology·R B HeathM D Robertson
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Tracey McLaughlinDavid E Cummings
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katherine E WortleyMark W Sleeman
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·H J LeidyN I Williams
Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dagmar A SchmidAxel Steiger
Sep 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Kelly C AllisonAlbert J Stunkard
Sep 1, 2005·European Journal of Endocrinology·Mina SuematsuYukihiko Adachi
Nov 15, 2005·Endocrine Journal·Chao Chun ZouZheng Yan Zhao
Jun 30, 2006·Neuroscience Letters·Eva Szentirmai, James M Krueger
Sep 30, 2006·Endocrinology·Rubén NogueirasCarlos Diéguez
Feb 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Zhi-Fu GuoZheng Zhang

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Citations

Nov 5, 2010·Indian Pediatrics·Nur ArslanAdem Aydin
Apr 25, 2013·World Journal of Gastroenterology : WJG·Celal UlasogluIlyas Tuncer
Jan 24, 2013·European Journal of Pediatrics·Despina HerouviKyriaki Karavanaki
Aug 12, 2009·Cytokine & Growth Factor Reviews·Inge SeimLisa K Chopin
Oct 16, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Katy Horner, SoJung Lee
Mar 23, 2010·Metabolism: Clinical and Experimental·Jaak JürimäeSerge P von Duvillard
Dec 14, 2011·Annals of Nutrition & Metabolism·Antonio LacquanitiMichele Buemi
Oct 26, 2013·Journal of Pediatric Gastroenterology and Nutrition·Prateek WaliKaroly Horvath
Jan 1, 2014·Terapevticheskiĭ arkhiv·I V Tereshchenko, P E Kaiushev

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