The changed ultrastructure of fibrin networks during use of oral contraception and hormone replacement.

Journal of Thrombosis and Thrombolysis
Etheresia PretoriusJohannes Henricus Meiring

Abstract

Contraceptives and hormone replacement have been extensively used since the late 1950s. However, adverse effects are common and include an increased risk of cardiovascular diseases, including thrombo-embolic diseases. Previous research has shown that ultrastructure of fibrin networks may provide great insight regarding the thrombotic potential of patients. The current study investigates the scanning electron microscopy (SEM) ultrastructure of fibrin networks of individuals using oral contraceptive therapy as well as individuals using hormone replacement. We compare micrographs of these two groups with micrographs of young, healthy individuals not using oral contraception. Platelet rich plasma and thrombin was used to prepare the fibrin clots. Here we show that during contraceptive and hormone replacement use, a netted fibrin layer forms. We suggest that oestradiol use causes fibrin network changes and these changes can be seen using SEM technology. These changes may provide further evidence regarding the increased occurrence of thrombotic events during contraceptive and hormone replacement therapy.

References

Mar 23, 2006·Gender Medicine·Saskia Middeldorp
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology·Dorit Blickstein, Isaac Blickstein
Feb 27, 2008·Microscopy Research and Technique·E PretoriusE Smit
Jun 24, 2008·Ultrastructural Pathology·Etheresia PretoriusCarl R Franz
Aug 9, 2008·Vascular Medicine·Suman Rathbun
Feb 17, 2009·Thrombosis Research·Saskia Middeldorp
Oct 16, 2009·Climacteric : the Journal of the International Menopause Society·M Canonico, P-Y Scarabin
Oct 16, 2009·Climacteric : the Journal of the International Menopause Society·R A Lobo
Nov 13, 2009·Climacteric : the Journal of the International Menopause Society·B WallbergN Wilking
Jan 1, 2008·Pathophysiology of Haemostasis and Thrombosis·E Pretorius
Jul 3, 2010·Ultrastructural Pathology·Etheresia PretoriusJohannes Henricus Meiring

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Citations

Oct 18, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Etheresia PretoriusHester M Oberholzer
Feb 3, 2016·Menopause : the Journal of the North American Menopause Society·Magdalena M PirógAnetta Undas
Oct 22, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Apr 16, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen, Etheresia Pretorius
Apr 11, 2012·Microscopy Research and Technique·Boguslaw LipinskiWendy Jeanette Van Der Spuy

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