The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models

Biochemical and Biophysical Research Communications
Xiaoying LianXiangmei Chen

Abstract

The pathogenic mechanism of polycystic kidney disease (PKD) is unclear. Abnormal glucose metabolism is maybe involved in hyper-proliferation of renal cyst epithelial cells. Mini-pigs are more similar to humans than rodents and therefore, are an ideal large animal model. In this study, for the first time, we systematically investigated the changes in glucose metabolism and cell proliferation signaling pathways in the kidney tissues of chronic progressive PKD mini-pig models created by knock-outing PKD1gene. The results showed that in the kidneys of PKD mini-pigs, the glycolysis is increased and the expressions of key oxidative phosphorylation enzymes Complexes I and IV significantly decreased. The activities of mitochondrial respiration chain Complexes I and IV significantly decreased; the phosphorylation level of key metabolism-modulating molecule AMP-activated protein kinase (AMPK) significantly decreased; and the mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK) signaling pathway are activated obviously. This study showed that in the kidneys of PKD mini-pigs, the level of glycolysis significantly increased, oxidative phosphorylation significantly decreased, and cell proliferation signaling p...Continue Reading

Citations

Nov 12, 2019·American Journal of Physiology. Renal Physiology·Susan GhaziAndrew M Hall
Dec 26, 2018·Clinical Kidney Journal·Thomas WeimbsBryan C Bourgeois
Aug 19, 2018·Nature Reviews. Nephrology·Valeria PadovanoMichael J Caplan
Aug 28, 2020·International Journal of Molecular Sciences·Sophie HaumannMax C Liebau

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