The changes in the expression levels of follicular markers in keratoacanthoma depend on the stage: keratoacanthoma is a follicular neoplasm exhibiting infundibular/isthmic differentiation without expression of CK15

Journal of Cutaneous Pathology
Noriyuki MisagoYutaka Narisawa

Abstract

Although the precise etiology of keratoacanthoma (KA) is unknown, KA is generally assumed to differentiate toward hair follicles based on previous studies of experimental carcinogenesis. We performed a comprehensive immunohistochemical study of various follicular markers in all stages of KA. A total of 67 tumors, including 16 early or proliferative stage lesions, 43 well-developed stage lesions, five regressing stage lesions and three regressed stage lesions, were subjected to the analysis. CK15 (clone C8/144B), CK19 and CD34 were not expressed at any stage. CK1, CK10, CK16, CK17, CK15 (clone LHK15) and calretinin showed dynamic changes in their expression in KA depending on the stage. KA is a follicular neoplasm with infundibular/isthmic (upper segmental region of hair follicles) differentiation. It is considered that early or proliferative stage tumors show keratin-filled invaginations with infundibular differentiation and gradual isthmic differentiation. Well-developed examples of KA generally show isthmic differentiation in the whole lesions. The regressed stage KAs lose the features of this type of follicular differentiation and show epidermal characteristics. No expression of CK15 (clone C8/144B) was observed in KAs, alth...Continue Reading

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Citations

Oct 14, 2014·Diseases·Katherine N Gibson-CorleyDavid K Meyerholz
Apr 23, 2014·Journal of Cutaneous Pathology·Noriyuki MisagoYutaka Narisawa
Dec 10, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Vivian Petersen WagnerCristiane Helena Squarize
Mar 24, 2017·The Journal of Dermatology·Noriyuki MisagoTomokazu Nakao
Mar 4, 2017·The Journal of Dermatology·Toshihiro Takai
Jan 2, 2020·Journal of Cutaneous Pathology·Priyadharsini Nagarajan
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Dec 10, 2014·Journal of Cutaneous Pathology·Steven Kossard
Jul 17, 2020·Cancer Reports·Sarita JoshiOle Petter F Clausen

Related Concepts

Cell Differentiation Process
Immunocytochemistry
Keratoacanthoma
TNM Staging System
Retrospective Studies
Malignant Neoplasm of Skin
Tumor Markers
Hair Follicle Structure
Keratin-15
Biological Markers

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