The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

Journal of Translational Medicine
Di LiuWei Wang

Abstract

Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension. Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20-68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography. Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with GP18 (P < 0.05/57). The canonical correlation analysis indicated that initial N-glycan structures, including GP4, GP6, GP9-12, GP14, GP17, GP18 and GP23, were significantly correlated with blood lipids, including total cholesterol, total triglycerides (TG) and low-density lipoprotein (r = 0.390, P < 0.001). IgG glycans patterns were able to distinguish patients with dyslipidaemia from the controls, with an area under the curve of 0.692 (95% confidence interval 0.644-0.740). Our findings indicated that a possible association between blood...Continue Reading

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Citations

Nov 21, 2018·Omics : a Journal of Integrative Biology·Qingwei MaWei Wang
Sep 11, 2019·Glycobiology·Brian A Cobb
Oct 28, 2019·Omics : a Journal of Integrative Biology·Wei Wang
Jan 7, 2021·Omics : a Journal of Integrative Biology·Medi KoriKazim Yalcin Arga
Aug 31, 2020·Molecular Aspects of Medicine·Tamara ŠtambukGordan Lauc
Feb 6, 2021·Npj Aging and Mechanisms of Disease·Xiaoyu ZhangYouxin Wang
Jan 26, 2021·Journal of Diabetes·Zhiyuan WuXiuhua Guo
Jun 3, 2021·International Journal of Molecular Sciences·Beatrix PatonNúria Canela
Feb 12, 2020·Analytica Chimica Acta·Cuiyan CaoXinmiao Liang
Jul 22, 2021·Journal of Hypertension·Domagoj KiferCristina Menni
Nov 23, 2021·Frontiers in Immunology·Xingang LiWei Wang

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Methods Mentioned

BETA
glycosylation
PCA

Software Mentioned

R
LASSO
SAS
R package “ corrplot
SPSS
R package “ forestplot ”
R package “ lars ”

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