PMID: 9437662Jan 23, 1998Paper

The changes of LCGU and rCBF in the MCA occlusion-recirculation model in rats and the ameliorating effect of MCI-186, a novel free radical scavenger

Molecular and Chemical Neuropathology
S Yuki, K Kogure

Abstract

We examined the change of regional cerebral blood flow (rCBF) and local cerebral glucose utilization (LCGU) in the middle cerebral artery (MCA) occlusion or recirculation model of rats, and tested anti-ischemic effects of a free radical scavenger, 3-methyl-1-phenyl-pyrazolon-5-one (MCI-186). A remarkable increase in LCGU was observed in the cortex supplied by the anterior cerebral artery after recirculation. This hypermetabolism of glucose was at least partly caused by the postischemic oxidative injury, since MCI-186 ameliorated the high LCGU in this area. These results suggested the usefulness of this type of free radical scavenger for inhibiting the postischemic injury.

References

Mar 1, 1978·The American Journal of Physiology·T J HougenT W Smith
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Kocher
Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K ShiraishiR P Simon
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·C BromontJ Bralet
Apr 1, 1988·Stroke; a Journal of Cerebral Circulation·K AbeK Kogure
Jul 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T WatanabeS Murota
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Nedergaard, J Astrup
Oct 1, 1994·Annals of Neurology·K A Hossmann

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Citations

Apr 21, 2005·The American Journal of Orthopsychiatry·Jennifer StuberGerry Fairbrother
Nov 7, 2003·Journal of Exposure Analysis and Environmental Epidemiology·Pierre VergerDenis Bard
Jan 27, 2018·Journal of Clinical Biochemistry and Nutrition·Kazutoshi WatanabeYorihiro Yamamoto

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