The changes of pattern electroretinography at the early stage of photodynamic therapy

Documenta Ophthalmologica. Advances in Ophthalmology
Ayse OnerKuddusi Erkilic

Abstract

To evaluate the short-term changes in pattern electroretinography (PERG) after photodynamic therapy (PDT). Thirty eyes of 30 patients (17 males, 13 females) with choroidal neovascularization secondary to age related macular degeneration were included in this study. Standard PDT with verteporfin was performed on each patient. Serial PERG recordings were performed before, 1 week, and 1 month after PDT. Mean age of the patients was 69.6+/-8.4 years (range 56 and 90 years). One month after PDT, the visual acuity improved in 16 eyes, remained unchanged in 12 eyes and deteriorated in two eyes. New hemorrhages were seen in two eyes in the first week after PDT and visual acuity was decreased in those patients. No other patient complained of ocular and systemic adverse events. There was a statistically significant reduction in the amplitudes of P50 and N95 waves at the first week recordings after PDT. At 1 month after PDT, no significant differences in the P50 and N95 amplitudes were observed compared with pre-PDT PERG recordings. There were no significant changes in the latencies of P50 and N95 at the first week and first month recordings when compared with pre-treatment PERG values. Reduction in P50 and N95 amplitudes suggests that tr...Continue Reading

References

Oct 18, 2002·American Journal of Ophthalmology·Adam H RogersCarmen A Puliafito
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Stephan Michels, Ursula Schmidt-Erfurth
May 8, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joachim WachtlinMichael H Foerster
Dec 10, 2003·Documenta Ophthalmologica. Advances in Ophthalmology·Libin JiangLezheng Wu
May 6, 2004·American Journal of Ophthalmology·Timothy Y Y LaiDennis S C Lam
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Monica VaranoAntonella Pascarella
Oct 18, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Michael BachSuresh Viswanathan

❮ Previous
Next ❯

Citations

Feb 13, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Timothy Y Y LaiDennis S C Lam
Mar 7, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Chun-Fu LiuLing Yeung
Jun 10, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Christina Gerth
Mar 17, 2010·Documenta Ophthalmologica. Advances in Ophthalmology·Emma J BerrowJonathan M Gibson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.