PMID: 16518125Mar 7, 2006Paper

The changes of propofol concentration in human cerebrospinal fluid after drug infusion

Clinical Neuropharmacology
Andrzej L DawidowiczMarek Mardarowicz

Abstract

Investigation of the propofol concentration changes in cerebrospinal fluid (CSF) after the termination of the drug infusion. Nine patients (American Society of Anesthesiologists classes I-III) scheduled for elective intracranial procedures were studied. Propofol was applied in the form of target control infusion. During anesthesia, fractional doses of fentanyl and cisatracurium were administered as necessary. After tracheal intubation, the lungs were ventilated to achieve normocapnia with an oxygen-air mixture (fraction of inspired oxygen = 0.33). Arterial blood and CSF samples (from an intraventricular drain) were taken simultaneously at the end of propofol infusion and then at 15, 30, 45, 60, 90, and 120 minutes after the end of infusion. A pronounced decrease of the anesthetic concentration in plasma (P < 0.001) was observed during the first 15 minutes after infusion termination, followed by further yet slower decrease of the drug concentration. At the end of propofol infusion, the concentration of propofol in CSF was 65.59 ng/mL (SD, 26.91 ng/mL) and remained almost stable for approximately 30 minutes; afterward, a slow decrease of CSF propofol concentration was observed. The statement that CSF can be regarded as a signific...Continue Reading

References

Jul 1, 1995·Journal of Chromatographic Science·A L Dawidowicz, A Fijalkowska
Apr 22, 1999·British Journal of Anaesthesia·O EngdahlC Eintrei
Jan 3, 2001·Microscopy Research and Technique·J F Ghersi-Egea, N Strazielle
Jul 30, 2002·Anesthesia and Analgesia·P Soeding, G Hoy
Oct 29, 2002·Anesthesia and Analgesia·Andrzej L DawidowiczAnna Fijalkowska
Dec 19, 2002·British Journal of Anaesthesia·A L DawidowiczT Trojanowski
Dec 4, 2003·British Journal of Clinical Pharmacology·Andrzej L DawidowiczAnna Fijalkowska
Jun 11, 2004·Clinical Neuropharmacology·Andrzej L DawidowiczAnna Fijalkowska

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Citations

Oct 9, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Revathy B IyerCatherine E Devine

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