The changing immunological paradigm in coeliac disease

Immunology Letters
P Brandtzaeg

Abstract

When coeliac disease is referred to as an inflammatory disorder, this may detract from its true nature. Activation of innate and adaptive immunity takes place in the mucosal lesion, but the tissue reaction is not that of classical inflammation. In fact, coeliac disease contrasts strikingly with typical inflammatory bowel disorders such as ulcerative colitis and Crohn's disease. The coeliac lesion apparently reflects, in the main, immune-driven remodelling of mucosal architecture with only a minor inflammatory component - initially most likely resulting from innate signals. Complement split products might be one of several potential initial hits that lead to activation of lamina propria and epithelial cells with release of mediators such as interleukin-15. This cytokine appears to stimulate potentially pathogenic intraepithelial lymphocytes. In genetically susceptible individuals, such early innate events could turn into persistent pathogenic signalling with subsequent adaptive cellular and humoral immunopathology resulting in a chronic lesion. Nevertheless, mucosal homeostasis is surprisingly well preserved as signified by the remarkable dominance of plasma cells that produce dimeric immunoglobulin A as a basis for enhanced sec...Continue Reading

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Citations

Feb 9, 2016·Food & Nutrition Research·Isabel CominoCarolina Sousa
Mar 23, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Huanbin XuKarol Sestak
Sep 30, 2008·Clinical and Experimental Immunology·D BernardoE Arranz
Apr 22, 2010·Journal of Cellular and Molecular Medicine·Barbara ChladkovaLudmila Tuckova
Nov 13, 2009·Scandinavian Journal of Immunology·P Brandtzaeg
Oct 7, 2015·International Journal of Paediatric Dentistry·Maurizio BossùAntonella Polimeni
Dec 20, 2014·Scandinavian Journal of Gastroenterology·Rasmus Goll, Atle van Beelen Granlund
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Jul 8, 2010·Nature Reviews. Gastroenterology & Hepatology·Per Brandtzaeg
Aug 10, 2010·Current Opinion in Gastroenterology·Per Brandtzaeg
Dec 20, 2008·Scandinavian Journal of Gastroenterology·Tamara VorobjovaRaivo Uibo
Nov 4, 2009·Scandinavian Journal of Gastroenterology·Per Brandtzaeg
Jun 15, 2007·Scandinavian Journal of Gastroenterology·Dorsaf ToumiIbtissem Ghedira
Jun 14, 2019·Frontiers in Plant Science·Manuel MartinezMercedes Diaz-Mendoza
Aug 1, 2020·Frontiers in Immunology·Margaret R DunneConleth Feighery
Mar 4, 2011·Journal of Agricultural and Food Chemistry·Daniel SánchezLudmila Tučková

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