The Changing Landscape in the Genetic Etiology of Human Tooth Agenesis

Genes
Meredith A Williams, Ariadne Letra

Abstract

Despite much progress in understanding the genetics of syndromic tooth agenesis (TA), the causes of the most common, isolated TA remain elusive. Recent studies have identified novel genes and variants contributing to the etiology of TA, and revealed new pathways in which tooth development genes belong. Further, the use of new research approaches including next-generation sequencing has provided increased evidence supporting an oligogenic inheritance model for TA, and may explain the phenotypic variability of the condition. In this review, we present current knowledge about the genetic mechanisms underlying syndromic and isolated TA in humans, and highlight the value of incorporating next-generation sequencing approaches to identify causative and/or modifier genes that contribute to the etiology of TA.

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Citations

Sep 25, 2018·Orthodontics & Craniofacial Research·Sonia MagruderAriadne Letra
Feb 6, 2020·Scientific Reports·Elias S OeschgerNikolaos Gkantidis
May 6, 2019·Journal of Orthodontics·Jayne Harrison
Oct 10, 2020·Journal of Dental Research·Y ZengA Letra
Dec 29, 2020·Orthodontics & Craniofacial Research·Meredith WilliamsAriadne Letra
Mar 13, 2021·International Journal of Dentistry·Kelvin I AfrashtehfarS Ross Bryant
Aug 7, 2021·Biology·Nikolaos GkantidisGeorgios Kanavakis

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Methods Mentioned

BETA
transgenic
exome sequencing

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