The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools

Current Opinion in Neurology
Peter BedePierre-François Pradat

Abstract

Neuroimaging in motor neuron disease (MND) has traditionally been seen as an academic tool with limited direct relevance to individualized patient care. This has changed radically in recent years as computational imaging has emerged as a viable clinical tool with true biomarker potential. This transition is not only fuelled by technological advances but also by important conceptual developments. The natural history of MND is now evaluated by presymptomatic, postmortem and multi-timepoint longitudinal imaging studies. The anatomical spectrum of MND imaging has also been expanded from an overwhelmingly cerebral focus to innovative spinal and muscle applications. In contrast to the group-comparisons of previous studies, machine-learning and deep-learning approaches are increasingly utilized to model real-life diagnostic dilemmas and aid prognostic classification. The focus from evaluating focal structural changes has shifted to the appraisal of network integrity by connectivity-based approaches. The armamentarium of MND imaging has also been complemented by novel PET-ligands, spinal toolboxes and the availability of magnetoencephalography and high-field magnetic resonance (MR) imaging platforms. In addition to the technological an...Continue Reading

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Citations

Jan 19, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Eoin FineganPeter Bede
Jul 12, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Peter Bede
Jul 17, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M AbidiP Bede
Aug 6, 2019·Frontiers in Neurology·Stacey Li Hi ShingPeter Bede
Oct 27, 2018·Frontiers in Neurology·Giorgia QuerinPierre-Francois Pradat
Dec 14, 2018·Frontiers in Neurology·Foteini ChristidiPeter Bede
Mar 16, 2019·Frontiers in Neuroscience·Vincent GrollemundPeter Bede
Apr 16, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Peter Bede, Rangariroyashe H Chipika
Jan 24, 2019·Frontiers in Neurology·Malcolm ProudfootMartin R Turner
Apr 30, 2019·Frontiers in Neurology·Mohamed Mounir El MendiliPierre-François Pradat
Mar 7, 2019·Frontiers in Neurology·Yana YunusovaPeter Bede
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Jan 11, 2020·Frontiers in Neurology·Peter Bede, Pierre-Francois Pradat
Jul 19, 2018·Frontiers in Neurology·Foteini ChristidiPeter Bede
Apr 4, 2019·Frontiers in Neurology·Rangariroyashe Hannah ChipikaPeter Bede
Jan 8, 2021·Brain Imaging and Behavior·Eoin FineganPeter Bede
Feb 16, 2021·Brain Imaging and Behavior·Elena RattiBradford C Dickerson
Feb 20, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Erik P PioroPeter Bede
Feb 27, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Stacey Li Hi ShingPeter Bede

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

NISALS
MND

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