The Changing Landscape of Renal Inflammation

Trends in Molecular Medicine
Thomas Ernandez, Tanya Norton Mayadas

Abstract

Kidney inflammation is a major contributor to progressive renal injury, leading to glomerulonephritis (GN) and chronic kidney disease. We review recent advances in our understanding of leukocyte accumulation in the kidney, emphasizing key chemokines involved in GN. We discuss features of renal inflammation such as the evolving concept of immune cell plasticity. We also describe certain aspects of organ-specific tissue microenvironments in shaping immune cell responses, as well as the current knowledge of how regulatory T lymphocytes impact on other immune effector cell populations to control inflammation. It is clear that present and future research in these areas may contribute to the development of novel targeted therapeutics, with the hope of alleviating the burden of end-stage renal disease (ESRD).

References

Aug 30, 1996·The Journal of Biological Chemistry·S M Santee, L B Owen-Schaub
Mar 19, 2003·The Journal of Experimental Medicine·Lynda BennettVirginia Pascual
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Jennifer R TimoshankoPeter G Tipping
Mar 25, 2005·Journal of the American Society of Nephrology : JASN·Dominik WolfAlexander R Rosenkranz
Apr 21, 2005·The Journal of Clinical Investigation·Volker VielhauerTanya N Mayadas
Aug 24, 2005·Nature Immunology·Gudrun F DebesEugene C Butcher
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rafia S Al-LamkiJohn R Bradley
Jun 1, 2007·Journal of the American Society of Nephrology : JASN·Ulf PanzerRolf A K Stahl
Jul 17, 2007·Medicine·Manuel Ramos-CasalsMunther A Khamashta
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Jan 12, 2008·Journal of Pharmacological Sciences·Kae TeramotoKatsuyuki Miura
Mar 14, 2008·Journal of the American Society of Nephrology : JASN·Julia MenkeVicki R Kelley
Jul 11, 2008·Expert Opinion on Drug Safety·Martin Aringer, Josef S Smolen
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Mar 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kui Shin VooYong-Jun Liu
Jun 6, 2009·Journal of the American Society of Nephrology : JASN·Gilbert R KinseyMark D Okusa
Jul 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lena SchifferMario Schiffer
Jul 25, 2009·Kidney International·Maria Teresa GandolfoHamid Rabb
Nov 18, 2009·Journal of the American Society of Nephrology : JASN·Kathrin EllerAntal Rot
Nov 18, 2009·Circulation·Tanya N MayadasNaotake Tsuboi
Dec 24, 2009·Journal of Leukocyte Biology·Uta E HöpkenMartin Lipp
Mar 20, 2010·Journal of the American Society of Nephrology : JASN·Jan-Eric TurnerUlf Panzer
Apr 9, 2010·Kidney International·Jan-Eric TurnerUlf Panzer
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Abdul HakkimArturo Zychlinsky
Jul 30, 2010·Trends in Molecular Medicine·Tanya N MayadasSanjeev Sethi
Nov 10, 2010·Immunology and Cell Biology·Clare Y SlaneyJacquie L Harper
Jan 21, 2011·Kidney International·Joshua D OoiA Richard Kitching
Apr 9, 2011·Journal of the American Society of Nephrology : JASN·Arthur C K Chung, Hui Y Lan
Apr 29, 2011·Kidney International·Hans-Joachim PaustGisa Tiegs
Jun 10, 2011·The Journal of Investigative Dermatology·H Jorn BovenschenHans J P M Koenen
Jul 15, 2011·Trends in Immunology·Jürgen SchellerStefan Rose-John
Sep 2, 2011·The Journal of Clinical Investigation·Douglas D McCarthyJeffrey L Browning
Sep 29, 2011·Nature Reviews. Rheumatology·Mariana J Kaplan
Dec 23, 2011·Kidney International·Li-Wen LaiYeong-Hau H Lien

❮ Previous
Next ❯

Citations

Dec 19, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jeremie M LeverJames F George
Feb 23, 2018·Oncotarget·Linlin ChenLing Zhao
May 14, 2017·Pharmacological Reports : PR·Hamed Haghi-AminjanMohammad Abdollahi
Aug 11, 2019·Current Topics in Medicinal Chemistry·F A Nogueira JúniorH S Azul Monteiro
Apr 17, 2020·Frontiers in Pharmacology·Ming XiaHong Liu
Apr 8, 2020·Frontiers in Cell and Developmental Biology·Yue-Yu GuHui-Yao Lan
Nov 25, 2017·Science China. Life Sciences·Chen ZhouXuan Zhang
Jan 31, 2020·Journal of the American Society of Nephrology : JASN·Ganeshkumar RajendranPinelopi P Kapitsinou
Mar 16, 2021·Frontiers in Medicine·Philip Chiu-Tsun TangPatrick Ming-Kuen Tang
Mar 30, 2021·Clinical Kidney Journal·Stephen J McWilliamLouise Oni
May 4, 2021·Seminars in Cell & Developmental Biology·Raza Ali NaqviAfsar R Naqvi
Jul 22, 2018·The Science of the Total Environment·Starlaine MascarenhasAnasuya Ganguly
Jul 8, 2021·American Journal of Physiology. Cell Physiology·Pei Xiong Liew
Jul 16, 2019·Life Sciences·Priscila Aparecida Costa ValadãoAline Silva de Miranda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved