PMID: 46184Mar 1, 1975

The changing management of childhood Hodgkin's disease

Cancer
C TanM L Murphy

Abstract

Between 1929 and September 1974, 211 children under 15 years of age with biopsy-proven Hodgkin's disease were treated at Memorial Sloan-Kettering Cancer Center. For analysis these patients were placed into three historical groups which displayed the most marked changes in diagnostic workup and therapy. They are as follows: Pre-1959-80 patients with "clinical" staging, local field radiation therapy, palliative chemotherapy; 1960-1969-86 patients with lymphangiographic staging, extended field radiation therapy, palliative chemotherapy; 1970-September 1974-45 patients with "contemporary" staging, including laparotomy, involved field radiation therapy, and/or multiple drug chemotherapy. Twenty-seven children with Stage IV disease at diagnosis or those with recurrent disease received this multiple drug regimen. This consisted of Adriamycin, followed by combined prednisone, procarbazine, and vincristine, then cyclophosphamide. Drug cycles were repeated every 3-4 months for a period of about 24 months. Twenty-five achieved remission, 20 complete and 5 partial. The median duration of complete remission was 18 plus months. This multidisciplinary management of Hodgkin's disease has shown early, encouraging results. Longer followup is nee...Continue Reading

References

Mar 1, 1973·Cancer·B SchnitzerD K Weaver
Apr 1, 1973·Archives of Surgery·D M HaysR E Hittle
Dec 1, 1970·Annals of Internal Medicine·V T DevitaP P Carbone
May 1, 1967·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·R D JenkinJ M Darte
Sep 1, 1965·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·F KELLY

Citations

Sep 1, 1977·Archives of Disease in Childhood·I E Smith, T J McElwain
Jan 1, 1994·International Journal of Radiation Oncology, Biology, Physics·S F ClearyS S Donaldson
Mar 1, 1987·Baillière's Clinical Haematology·J E Kingston
Jan 1, 1981·Medical and Pediatric Oncology·J C AllenM Brown
Jul 1, 1981·Head & Neck Surgery·R B Raney, S D Handler
May 1, 1980·The Journal of Pediatrics·J C DearthR E Cupps
Jul 1, 1990·Clinical Oncology : a Journal of the Royal College of Radiologists·R Glynne-JonesP N Plowman
Jun 15, 1984·Cancer·D Potaznik, P G Steinherz
Mar 1, 1975·Cancer·M L Murphy
Feb 15, 1980·Cancer·P G SteinherzD R Miller
Jan 1, 1980·World Journal of Surgery·P R Exelby
Apr 1, 1983·Pediatric Annals·C T Tan, K W Chan
Jan 1, 1981·Pediatric Radiology·R G AppellW E Brandeis
Feb 1, 1976·Postgraduate Medicine·W W Sutow, M P Sullivan

Related Concepts

Antineoplastic Agents
Cyclophosphamide, (S)-Isomer
Ribodoxo
Polychemotherapy
Hodgkin Lymphoma, Lymphocyte Depletion
Palliative Surgery
Procarbazine Monohydrobromide
Remission, Spontaneous
Cellcristin

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