Apr 1, 1976

The changing pattern of bacterial sepsis since the introduction of antibiotic therapy

Journal of the American Geriatrics Society
H Seneca, J P Grant

Abstract

During the six-year period, 1968-1973, sepsis developed in 1 of every 80 patients admitted to the Presbyterian Hospital, New York. In 1 of 133 patients the sepsis was due to Gram-positive organisms, and in 1 of 188 patients to Gram-negative organisms. The mortality rate for Gram-positive cases was 4.4 percent, for Gram-negative cases 19.1 percent, and for urologic cases 15.3 percent (versus 56.25 percent in 1959-1964). Data are presented on the relative incidences of involved pathogens in 1740 cases of Gram-positive sepsis /78 deaths), and in 1236 cases of Gram-negative sepsis (205 deaths). The lowering of the sepsis mortality rate has been the result of preventative measures, early diagnosis, and vigorous treatment. Treatment includes the correction of acidosis and anoxia, early administration of bactericidal antibiotics, and restoration of the microcirculation by administration of corticosteroids, beta-adrenergic drugs, and appropriate diuretics.

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References

Mentioned in this Paper

Septicemia
Antibiotic throat preparations
Antifungal Antibiotics, Topical
Corticosteroids, topical for treatment of hemorrhoids and anal fissures
Antibiotics, Gynecological
Endotoxic Shock
Adrenal Cortex Hormones
Corticosteroid otologicals
Glucocorticoid Effect
Antibiotics for systemic use

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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