The Changing Profile of Helicobacter pylori Antibiotic Resistance in Singapore: A 15-Year Study

Helicobacter
Tiing Leong AngSubbiah Dhamodaran

Abstract

Antibiotic resistance is an important cause of H. pylori treatment failure. This study aimed to examine the change in H. pylori antibiotic resistance profile in Singapore over the course of 15 years. The study period was from 2000 to 2014. Gastric mucosal biopsies obtained from H. pylori-positive patients were cultured. Antibiotic susceptibility to metronidazole, clarithromycin, levofloxacin, tetracycline, and amoxicillin was tested. The change in resistance rates over time was analyzed. A total of 708 H. pylori isolates were cultured. There was a significant increase in resistance rates for metronidazole (2000-2002: 24.8%; 2012-2014: 48.2%; p < .001), clarithromycin (2000-2002: 7.9%; 2012-2014: 17.1%; p = .022), and levofloxacin (2000-2002: 5%; 2012-2014: 14.7%; p = .007). The resistance rates for tetracycline (2000-2002: 5%; 2012-2014: 7.6%) and amoxicillin (2000-2002: 3%; 2012-2014: 4.4%) remained stable. Increase in dual (2000-2002: 6.9%; 2012-2014: 9.4%; p = .479) and triple antibiotic resistance rates (2000-2002: 0; 2012-2014: 7.6%; p < .001) were observed. Overall, the most common dual and triple resistance patterns were metronidazole/clarithromycin (4.4%) and metronidazole/clarithromycin/levofloxacin (1.8%), respectivel...Continue Reading

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Citations

May 17, 2002·The American Journal of Gastroenterology·Hiroto MiwaNobuhiro Sato
Nov 3, 2016·Therapeutic Advances in Gastroenterology·Yuko AkazawaYutaka Fukuda
Sep 30, 2017·The Journal of Antimicrobial Chemotherapy·Mei-Jyh ChenUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
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Jul 14, 2017·Current Opinion in Infectious Diseases·Claudio AlbaTeresa Alarcón
Mar 21, 2017·Digestive Diseases and Sciences·Yi HuNong-Hua Lu
May 23, 2017·Frontiers in Cellular and Infection Microbiology·Yi HuNong-Hua Lu
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Jun 18, 2020·Infection and Drug Resistance·Gebremicheal Gebreslassie KasahunDesilu Mahari Desta
Dec 27, 2019·Gut and Liver·Tiing Leong Ang, Daphne Ang

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