Natural killer (NK) cells have emerged as a particular focus of interest in transplantation due to their ability to distinguish allogeneic major histocompatibility complex (MHC) antigens and their potent cytolytic effector mechanisms. Once relegated to the field of bone marrow transplantation, NK cells have recently been shown to participate in the immune response against solid organ allo- and xenografts. These new findings suggest that the role of NK cells in solid organ rejection and tolerance needs to be reexamined.
"Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype
Evidence that early acute renal failure may be mediated by CD3- CD16+ cells in a kidney graft recipient with large granular lymphocyte proliferation
Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice
Immunologic diagnosis of kidney rejection using FACS analysis of graft-infiltrating functional and activated T and NK cell subsets
Abrogation of resistance to bone marrow transplantation by induction of specific tolerance in natural killer cells?
Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection
Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells
T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection
MHC class II expression on human heart microvascular endothelial cells: exquisite sensitivity to interferon-gamma and natural killer cells
Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors
Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period
Altered expression of Ly-49 receptors on NK cells developing in mixed allogeneic bone marrow chimeras
Early increased chemokine expression and production in murine allogeneic skin grafts is mediated by natural killer cells
Development of an ex vivo model of pig kidney perfused with human lymphocytes. Analysis of xenogeneic cellular reactions
Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primates
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
Porcine aortic endothelial cells transfected with HLA-G are partially protected from xenogeneic human NK cytotoxicity
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
Basics of immune responses in transplantation in preparation for application of composite tissue allografts in plastic and reconstructive surgery: part I
Anti-LFA-1 improves pig islet xenograft function in diabetic mice when long-term acceptance is induced by CTLA4Ig/anti-CD40L
Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells
Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis
KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation
Two-stage, in silico deconvolution of the lymphocyte compartment of the peripheral whole blood transcriptome in the context of acute kidney allograft rejection
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
Rapid increase of interleukin-10 plasma levels after combined auxiliary liver-kidney transplantation in presensitized patients
Potential role of NK cells in the induction of immune responses: implications for NK cell-based immunotherapy for cancers and viral infections
Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology
Both innate and adaptive major histocompatibility complex class I-dependent immunity impair long-term islet xenograft survival
Brief report--human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes
Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes
Global unresponsiveness as a mechanism of natural killer cell tolerance in mixed xenogeneic chimeras
Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism
Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity
Blood And Marrow Transplantation
The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.
Cancer Biology: Molecular Imaging
Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.
Allogenic & Autologous Therapies
Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.