The changing scenario of hepatocellular carcinoma in Italy: an update.

Liver International : Official Journal of the International Association for the Study of the Liver
Francesca GarutiITA.LI.CA study group

Abstract

Epidemiology of hepatocellular carcinoma (HCC) is changing in most areas of the world. This study aimed at updating the changing scenario of aetiology, clinical presentation, management and prognosis of HCC in Italy during the last 15 years. Retrospective analysis of the Italian Liver Cancer (ITA.LI.CA) database included 6034 HCC patients managed in 23 centres from 2004 to 2018. Patients were divided into three groups according to the date of cancer diagnosis (2004-2008, 2009-2013 and 2014-2018). The main results were: (i) a progressive patient ageing; (ii) a progressive increase of non-viral cases and, particularly, of 'metabolic' and 'metabolic + alcohol' HCCs; (iii) a slightly decline of cases diagnosed under surveillance, but with an incremental use of the semiannual schedule; (iv) a favourable cancer stage migration; (v) an increased use of radiofrequency ablation to the detriment of percutaneous ethanol injection; (vi) improved outcomes of ablative and transarterial treatments; (vii) an improved overall survival (adjusted for the lead time in surveyed patients) in the last calendar period, particularly in viral patients; (viii) a large gap between the number of potential candidates (according to oncologic criteria and age...Continue Reading

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Citations

Dec 2, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Edoardo G Giannini
Mar 7, 2021·Cancers·Filippo Pelizzaro On Behalf Of Ita Li Ca Study Group
Mar 16, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Teh-Ia HuoPing-Hsing Tsai
Dec 24, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giovanni MarascoUNKNOWN Italian Liver Cancer (ITA.LI.CA.) group

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