The characterisation of selected antidepressant drugs using electrospray ionisation with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their determination by high-performance liquid chromatography/electrospray ionisation tandem mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
W Franklin SmythEdmund O'Kane

Abstract

The electrospray ionisation ion trap tandem mass spectrometry (ESI-MS(n)) of selected antidepressant drugs, i.e., citalopram, fluoxetine, mirtazapine, paroxetine, sertraline, and venlafaxine, has been investigated. Sequential product ion fragmentation experiments (MS(n)) have been performed in order to elucidate the degradation pathways for the [M+H](+) ions and their predominant product ions. These MS(n) experiments show certain characteristic fragmentations in that functional groups are generally cleaved from the ring systems as molecules such as H(2)O, amines and phenols. When an aromatic entity is present in a drug molecule together with a nitrogen-containing saturated ring structure as with mirtazapine, fragmentation initially occurs at the latter ring with the former being predictably resistant to fragmentation. Also, when an amine-containing drug molecule such as fluoxetine also contains a functional group, which liberates a phenol with a significantly lower DeltaH(f) (0) value than that of the corresponding amine, the phenol is preferentially liberated. The structures of product ions proposed for ESI-MS(n) can be supported by electrospray ionisation quadrupole-time-of-flight tandem mass spectrometry (ESI-QToF-MS/MS). Th...Continue Reading

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Citations

May 9, 2007·Analytical and Bioanalytical Chemistry·Frank Musshoff, Burkhard Madea
Oct 8, 2008·International Journal of Legal Medicine·Sarah M R WilleWilly E Lambert
Jul 29, 2008·Journal of the American Society for Mass Spectrometry·Nuno ValePaula Gomes
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Feb 5, 2013·Journal of Mass Spectrometry : JMS·Bharathi AvulaLarry A Walker
May 31, 2018·Rapid Communications in Mass Spectrometry : RCM·Manuela VayGerd Mikus
Feb 29, 2020·Drug Testing and Analysis·Maximilian MethlingSven Hartwig

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