The characteristic cellular organization and CEACAM1 expression in the junctional epithelium of rats and mice are genetically programmed and not influenced by the bacterial microflora

Journal of Periodontology
R HeymannB Obrink

Abstract

The epithelial cell adhesion molecule CEACAM1 exhibits an interesting dynamic expression during tooth development. It is first expressed in the reduced enamel epithelium, its expression then increases in the orally faced reduced epithelium and the overlying oral epithelium that then fuse to give rise to the junctional epithelium. The expression of CEACAM1 remains at high levels in the junctional epithelium, in contrast to the surrounding oral sulcular epithelium which shows much lower expression levels. We investigated if the high expression levels of CEACAM1 and the loosely organized cells characteristic of the junctional epithelium are genetically programmed or result from bacterial infiltration. Oral tissues from germ-free rats and mice and animals with conventional bacterial flora were analyzed by transmission electron microscopy and immunohistochemical staining for CEACAM1. The junctional epithelium of both germ-free and conventional animals was identical with respect to both CEACAM1 expression and morphology. Also the presence of leukocytes was the same in both types of animals. The results indicate that the characteristic morphology and the high expression levels of CEACAM1 in the junctional epithelium are genetically pr...Continue Reading

References

Dec 1, 1979·Journal of Periodontology·A YamasakiN Ijuhin
Nov 1, 1975·Journal of Periodontology·M A Listgarten
Jul 1, 1992·Journal of Periodontal Research·J M Crawford
Oct 1, 1989·Calcified Tissue International·A BjurholmM Schultzberg
Sep 1, 1986·Journal of Periodontal Research·S HashimotoM Shimono
Jul 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P OdinB Obrink
Oct 1, 1971·Archives of Oral Biology·M A Listgarten, J B Heneghan
Jan 1, 1995·Connective Tissue Research·C LüningB Rozell
Sep 1, 1994·Anatomy and Embryology·A RassB Obrink
Oct 23, 1997·Current Opinion in Cell Biology·B Obrink
Aug 15, 2001·Experimental Cell Research·N BeaucheminW Zimmermann
May 8, 1959·Annals of the New York Academy of Sciences·B E GUSTAFSSON

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Citations

Jan 7, 2005·Journal of Periodontology·Douglas R DixonRichard P Darveau
May 17, 2012·Journal of Periodontal Research·Y TsukamotoM Nakamura
Sep 19, 2012·European Journal of Oral Sciences·Hong Huynh-TorlakovicInger J S Blix
Feb 26, 2013·Cellular Microbiology·Camille ZenobiaRichard P Darveau
Apr 17, 2015·Journal of Periodontology·Koichiro IrieRichard P Darveau
Dec 8, 2015·Cellular Microbiology·Maryta N SztukowskaRichard J Lamont
May 3, 2014·Scientific Reports·Sara Yajima-HimuroMatsuo Yamamoto
Dec 24, 2004·Journal of Dental Research·D D Bosshardt, N P Lang
Jul 16, 2014·Journal of Dental Research·M K AlotaibiC F Shuler
Mar 11, 2021·Periodontology 2000·Matsuo Yamamoto, Ryo Aizawa
Mar 11, 2021·Periodontology 2000·Ana M ChangRichard P Darveau

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