The characteristics of pallidal low-frequency and beta bursts could help implementing adaptive brain stimulation in the parkinsonian and dystonic internal globus pallidus

Neurobiology of Disease
Dan Piña-FuentesMartijn Beudel

Abstract

Adaptive deep brain stimulation (aDBS) has been applied in Parkinson's disease (PD), based on the presence of brief high-amplitude beta (13-35 Hz) oscillation bursts in the subthalamic nucleus (STN), which correlate with symptom severity. Analogously, average low-frequency (LF) oscillatory power (4-12 Hz) in the internal globus pallidus (GPi) correlates with dystonic symptoms and might be a suitable physiomarker for aDBS in dystonia. Characterization of pallidal bursts could facilitate the implementation of aDBS in the GPi of PD and dystonia patients. We aimed to describe the bursting behaviour of LF and beta oscillations in a cohort of five GPi-DBS PD patients and compare their amplitude and length with those of a cohort of seven GPi-DBS dystonia, and six STN-DBS PD patients (n electrodes = 34). Furthermore, we used the information obtained to set up aDBS and test it in the GPi of both a dystonia and a PD patient (n = 2), using either LF (dystonia) or beta oscillations (PD) as feedback signals. LF and beta oscillations in the dystonic and parkinsonian GPi occur as phasic, short-lived bursts, similarly to the parkinsonian STN. The amplitude profile of such bursts, however, differed significantly. Dystonia showed higher LF burst...Continue Reading

Citations

Sep 5, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Ute SchellerAndrea A Kühn
Oct 4, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackGünther Deuschl
Jul 9, 2020·Experimental Brain Research·Stephen Tisch, Patricia Limousin
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Jan 5, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Wolf-Julian NeumannR Mark Richardson
Dec 11, 2020·Brain : a Journal of Neurology·Yasmine M KehnemouyiHelen M Bronte-Stewart
Dec 1, 2020·Frontiers in Human Neuroscience·Sebastián Castaño-CandamilMichael Tangermann
Aug 2, 2020·Brain Stimulation·Dan Piña-FuentesMartijn Beudel
Oct 15, 2020·Journal of Neural Engineering·Matteo VissaniAlberto Mazzoni
Jul 31, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Alberto AvernaSara Meoni
Nov 23, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Jorge Dornellys da Silva LapaRubens Gisbert Cury

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