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The characteristics of the microsomal hydroxylation of tolbutamide

Canadian Journal of Physiology and Pharmacology

Mar 1, 1991

P M Bélanger, S St-Hilaire

Abstract

The in vitro metabolism of tolbutamide to the hydroxymethyl derivative was studied using hepatic microsomal homogenates. The hydroxymethyl metabolite was quantitated by HPLC. The hepatic microsomal hydroxylase was completely inhibited by carbon monoxide and was NADPH dependent. Metyrapo...read more

Mentioned in this Paper

Metabolic Process, Cellular
Pdia3
20-Methylcholanthrene
Isosafrole, (E)-isomer
Phenelzine
Depressed - Symptom
Cavia
Artosin
Metyrapone
August Rats
Paper Details
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The characteristics of the microsomal hydroxylation of tolbutamide

Canadian Journal of Physiology and Pharmacology

Mar 1, 1991

P M Bélanger, S St-Hilaire

PMID: 2059905

DOI: 10.1139/y91-061

Abstract

The in vitro metabolism of tolbutamide to the hydroxymethyl derivative was studied using hepatic microsomal homogenates. The hydroxymethyl metabolite was quantitated by HPLC. The hepatic microsomal hydroxylase was completely inhibited by carbon monoxide and was NADPH dependent. Metyrapo...read more

Mentioned in this Paper

Metabolic Process, Cellular
Pdia3
20-Methylcholanthrene
Isosafrole, (E)-isomer
Phenelzine
Depressed - Symptom
Cavia
Artosin
Metyrapone
August Rats

Similar Papers Found In These Feeds

Oxygenation & Hydroxylation

Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.

Mechanisms of CYP450

Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.

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Paper Details
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  • Citations7
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