PMID: 7581575Apr 1, 1995Paper

The characteristics of the participation of the neostriatal cholinergic system in regulating different forms of defensive behavior

Fiziologicheskiĭ zhurnal imeni I.M. Sechenova
K B ShapovalovaT A Diubkacheva

Abstract

The effects of microinjections of the cholinergic agonist (carbacholine) into the dorsal part of the neostriatum on discrimination processing of sensory signals were studied in chronic experiments in dogs (instrumental defensive reflex connected with maintenance of flexion posture) and in rats (active avoidance learning in T-maze). It was found that an improvement of discrimination process after carbacholine injections was manifested as an increase in the number of correct responses during acquisition of discriminative avoidance reflex in T-maze (rats) and during differentiation of sound signals in instrumental defensive reaction (dogs). The efficacy of this influences was suggested to be depend on the level of animal learning. We did not shown an improvement of the responses in two cases: 1. When before the microinjections the responses on the defensive and on the discriminative signals did not distinguish; 2. Under total differentiation of signals (e. g. under total learning). In both cases the neostriatum seems to be not involved in behavioral reaction what could be accompanied by low neuronal activity during the these signals action.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.