The characteristics of vessel lining cells in normal spleens and their role in the pathobiology of myelofibrosis

Blood Advances
Jiajing QiuRonald Hoffman

Abstract

The CD34-CD8α+, sinusoid lining, littoral cells (LCs), and CD34+CD8α-, splenic vascular endothelial cells (SVECs) represent 2 distinct cellular types that line the vessels within normal spleens and those of patients with myelofibrosis (MF). To further understand the respective roles of LCs and SVECs, each was purified from normal and MF spleens, cultured, and characterized. Gene expression profiling indicated that LCs were a specialized type of SVEC. LCs possessed a distinct gene expression profile associated with cytoskeleton regulation, cellular interactions, endocytosis, and iron transport. LCs also were characterized by strong phagocytic activity, less robust tube-forming capacity and a limited proliferative potential. These characteristics underlie the role of LCs as cellular filters and scavengers. Although normal LCs and SVECs produced overlapping as well as distinct hematopoietic factors and adhesion molecules, the gene expression profile of MF LCs and SVECs distinguished them from their normal counterparts. MF SVECs were characterized by activated interferon signaling and cell cycle progression pathways and increased vascular endothelial growth factor receptor, angiopoietin-2, stem cell factor, interleukin (IL)-33, Not...Continue Reading

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May 28, 2019·Journal of Thrombosis and Haemostasis : JTH·Laura L SwystunDavid Lillicrap
Nov 22, 2019·IUBMB Life·Maria ZingarielloAnna Rita Migliaccio
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Feb 16, 2020·Cell·Joanna KaluckaPeter Carmeliet

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