The characteristics required for a Sendai virus preparation to induce high levels of interferon in human lymphoblastoid cells

The Journal of General Virology
M D Johnston

Abstract

The capacity of an egg-grown Sendai virus preparation to induce interferon in the human lymphoblastoid cell Namalwa is dependent on its passage history. Virus which has been serially passaged at high dilution is a poor inducer, whereas virus serially passaged undiluted is a good inducer. Such a good induce preparation has a low infectivity to haemagglutination ratio as the result of a high content of defective-interfering (DI) particles. Using DI particles purified on glycerol gradients, it is shown that for the induction of maximum interferon titres both infectious and DI particles are required. DI particles alone induce little or no interferon. Addition of DI particles to fully infectious Sendai virus preparations increased the interferon yield obtained from Namalwa cells some 60- to 100-fold.

Citations

Apr 1, 1985·Applied Biochemistry and Biotechnology·H BorgE Lundgren
Jul 30, 2008·The Journal of Experimental Medicine·César Muñoz-FontelaStuart A Aaronson
Jan 1, 1985·Journal of Interferon Research·B LundE Lundgren
Aug 1, 1989·Journal of Interferon Research·R M MartinsR R Golgher
Jul 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P Mattana, G C Viscomi
Aug 26, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stephen Goodbourn, Richard E Randall
Nov 24, 2012·Journal of Virology·L Martínez-GilP Palese
Apr 1, 1983·The British Journal of Radiology·A JermyR C Rees
Nov 10, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Li-Wen LiuYasufumi Kaneda
Feb 14, 2015·Virus Research·Marian J KillipRichard E Randall
Dec 20, 2007·The Journal of General Virology·Richard E Randall, Stephen Goodbourn
Oct 20, 2006·Virology·Kay ChildsStephen Goodbourn
Apr 25, 2006·Virology·Laura StrahleDaniel Kolakofsky
Sep 1, 1987·European Journal of Cancer & Clinical Oncology·A JermyR C Rees
May 30, 2014·Journal of Virology·Carolina B López
Sep 13, 2019·Journal of Virology·Tahmina SultanaTatsuo Shioda
May 13, 1999·Journal of Biomedical Materials Research·M P FerrazJ D Santos
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacob S YountCarolina B López
Jun 5, 2019·Nature Microbiology·Marco Vignuzzi, Carolina B López
Nov 10, 2011·Critical Reviews in Biochemistry and Molecular Biology·Annie M Bruns, Curt M Horvath
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacob S YountCarolina B López
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wataru IchikawaRenzo Hirayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.