The characterization of a concentration-sensitive α-adrenergic-like octopamine receptor found on insect immune cells and its possible role in mediating stress hormone effects on immune function

Brain, Behavior, and Immunity
Jia HuangGongyin Ye

Abstract

Octopamine (OA), the insect equivalent of norepinephrine, links the nervous system and immune system in insects. This study examines the underlying molecular mechanisms (i.e. second messenger systems) mediating OA effects on insect immune cells. At low concentrations (<1μM), OA stimulatedhemocyte spreading and phagocytosis in the larval Lepidopteran (caterpillar) Chilo suppressalis, whereas at high concentrations (>10 μM), OA inhibited hemocyte spreading and phagocytosis. Similarly, OA concentration had differential effects on two intracellular signaling pathways, Ca(2+) and cAMP. Low concentrations of OA increased intracellular Ca(2+), but only high concentrations of OA (>1 μM) led to an increase in both Ca(2+) and cAMP. We identified an α-adrenergic-like octopamine receptor in this species (CsOA1) and confirmed that it is expressed in hemocytes. After heterologous expression in HEK-293 cells, the CsOA1 receptor produced the same OA concentration-dependent responses on intracellular Ca(2+) and cAMP as had been observed in hemocytes. These findings support earlier work showing that OA has both stimulatory and suppressive effects on immune responses, depending on the OA concentration. Our evidence suggests that these biphasic ef...Continue Reading

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Citations

Apr 23, 2013·Developmental and Comparative Immunology·Shunfan WuGongyin Ye
Sep 5, 2014·Journal of Neurochemistry·Yi-Xiang QiGong-Yin Ye
Nov 20, 2016·Journal of Evolutionary Biology·L WoestmannM Saastamoinen
Feb 1, 2017·BMC Biology·Philipp Bauknecht, Gáspár Jékely
Dec 25, 2016·The Journal of Experimental Biology·Shelley A AdamoCatherine Reeve
Sep 17, 2016·The Journal of Experimental Biology·Shelley A AdamoCarol I Miles
Jun 27, 2018·Pharmacological Reviews·Raul R GainetdinovMark D Berry
Mar 24, 2016·Insect Molecular Biology·R-Y XiaJ Huang
Oct 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milena JankowskaMaria Stankiewicz
Jan 1, 2012·Insects·Naïla EvenAndrew B Barron
Jun 13, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Shelley A Adamo
Jan 29, 2021·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Shelley A Adamo
Mar 3, 2020·Journal of Insect Physiology·Scott D CinelAkito Y Kawahara
Jun 12, 2016·Developmental and Comparative Immunology·Shelley Anne Adamo

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