PMID: 6642054Jan 1, 1983

The characterization of the linoleic acid desaturation and elongation system in ovine placental tissue

The International Journal of Biochemistry
J H Shand, R C Noble

Abstract

The desaturation and elongation of linoleic acid has been studied in homogenates and in subfractions of ovine placental tissue. The reaction was characterized in terms of pH and temperature optima, time course and protein concentration. Activity was found to be confined to the 11,000 g supernatant fraction of the tissue and the results suggest that the enzymes are membrane bound. The cytosolic fraction and ATP were required for full activity and the reaction was inhibited by cyanide. The properties of the reaction are compared with those of other desaturation systems and their implications with regard to possible reaction mechanisms are discussed.

References

Mar 24, 1975·Biochimica Et Biophysica Acta·E L Pugh, M Kates
Sep 2, 1968·Biochimica Et Biophysica Acta·Y L MarcelR T Holman
Apr 20, 1964·Biochimica Et Biophysica Acta·A GELLHORN, W BENJAMIN
Jul 2, 1962·Biochimica Et Biophysica Acta·J B MARSH, A T JAMES

Citations

Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J H Shand, R C Noble
Jun 15, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Nisha WadhwaniSadhana Joshi
Jan 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P L BiagiA Bordoni
Dec 1, 1994·Placenta·J P StammersP D Rossdale

Related Concepts

Hydrogen-Ion Concentration
Linoleic Acids
Microsomes
Placenta
Dall Sheep
Linoleic Acid, Sodium Salt, (Z, Z)-Isomer
Acyl CoA Desaturases

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