The Charcot joint: a modern neurologic perspective

Journal of Clinical Neuromuscular Disease
Kara A Chisholm, James M Gilchrist

Abstract

The Charcot joint, or Charcot neuroarthropathy, is a syndrome that was described over 140 years ago but one with very little exposure in the neurologic literature. We present a case recently seen and then discuss the history, epidemiology, pathophysiology, clinical features, and diagnosis of acute and chronic Charcot joint disease with particular emphasis on the value and limitations of imaging. A diagnostic algorithm is proposed. We also review the therapeutic strategies available for acute and chronic Charcot joints with a treatment algorithm. This review is aimed at enhancing the awareness of neurologists regarding Charcot neuroarthropathy, because they are often the principal caregivers for patients with peripheral neuropathy. We hope to promote early detection of acute Charcot neuroarthropathy, thereby reducing or preventing the bony deformation of chronic Charcot neuroarthropathy.

References

Jan 29, 1976·The New England Journal of Medicine·M E LevinL V Avioli
Jan 1, 1990·Skeletal Radiology·J BeltranM McCalla
Dec 1, 1984·Diabetologia·A G ArcherP J Watkins
Mar 1, 1994·Diabetes Care·P R CavanaghA J Boulton
Jan 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·P L SelbyA J Boulton
May 1, 1993·Foot & Ankle·M S PinzurA Zmuda
Nov 1, 1995·Skeletal Radiology·R H GoldL L Seeger
Mar 1, 1997·Annals of the Rheumatic Diseases·S AdamiV Braga
May 1, 1997·Diabetic Medicine : a Journal of the British Diabetic Association·D G ArmstrongT R Bushman
Jul 1, 1997·Diabetic Medicine : a Journal of the British Diabetic Association·A GoughM E Edmonds
Jul 1, 1997·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·W P GrantA I Vinik
Apr 8, 1998·The Journal of Bone and Joint Surgery. American Volume·D G Armstrong, L A Lavery
Apr 18, 1998·The Journal of Bone and Joint Surgery. British Volume·P AbrahamJ L Saumet
Nov 3, 1998·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·M ChildsG W Edelson
Jan 8, 1999·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·J R HanftM Surprenant
May 3, 2000·Clinical Rheumatology·R ChappelJ J Martin
Sep 14, 2000·The New England Journal of Medicine·B E Sumpio
Dec 5, 2000·Foot & Ankle International·M S PinzurA Evans
Aug 22, 2002·Diabetologia·S M RajbhandariS Tesfaye
Sep 26, 2003·Annals of Vascular Surgery·Lieke LeeBauer Sumpio
Apr 6, 2004·Foot and Ankle Clinics·Christopher W DiGiovanni
May 6, 2004·The Journal of Bone and Joint Surgery. British Volume·S A HerbstC L Saltzman
May 20, 2004·Diabetes/metabolism Research and Reviews·Lee J Sanders
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyUNKNOWN Infectious Diseases Society of America
Oct 14, 2004·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·John J AndersonAllen M Jacobs
Feb 1, 2005·Foot & Ankle International·Elly TrepmanMichael S Pinzur
Sep 24, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·M Edmonds, A Foster
Nov 18, 2005·Lancet·Peter R CavanaghGeorgeanne Botek
Feb 16, 2006·Diabetologia·C ChristodoulidesR Vettor
May 17, 2006·Foot & Ankle International·Michael S PinzurMatthew Posner
Aug 1, 1917·Annals of Surgery·L Eloesser
Apr 30, 2008·Diabetes/metabolism Research and Reviews·N L Petrova, M E Edmonds

❮ Previous
Next ❯

Citations

Aug 7, 2013·Diabetic Foot & Ankle·Gökhan KaynakTahir Oğüt
Oct 8, 2013·Diabetic Foot & Ankle·Ryan DoneganPeter A Blume
Nov 26, 2013·Diabetic Foot & Ankle·Fatma Bilge ErgenAli Oznur
Oct 5, 2014·Clinics in Podiatric Medicine and Surgery·Crystal L RamanujamThomas Zgonis
Dec 4, 2013·Clinics in Podiatric Medicine and Surgery·Peter A BlumeRyan Donegan
Jul 28, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jeremy MolliganZijun Zhang
Apr 23, 2016·Annals of Physical and Rehabilitation Medicine·Christelle NguyenFrançois Rannou
Sep 5, 2015·La Presse médicale·Fanny ReinhartDominique Stephan
Nov 5, 2016·Foot & Ankle International·Patrick K StrotmanMichael S Pinzur
Apr 18, 2018·The Journal of Bone and Joint Surgery. American Volume·Andrew Dodd, Timothy R Daniels
Nov 18, 2017·BMC Musculoskeletal Disorders·Martin BerliCharlotte Baltin
Feb 5, 2015·Acta Medica (Hradec Králové)·Tomáš KučeraJaromír Šrot
Jul 3, 2016·The Journal of Rheumatology·Mai Nguyen, Christine A Peschken
Oct 24, 2017·Journal of the Chinese Medical Association : JCMA·Mehmet B ÇildağDavid G Armstrong
Jun 15, 2012·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Awad AlaiRobert J Spinner
Feb 15, 2014·Journal of Korean Neurosurgical Society·Soo-Bum SonWhan Eoh
Apr 18, 2020·Journal of the American Veterinary Medical Association·Adam M TownsendErin E Epperly
Jul 31, 2020·Journal of the American Podiatric Medical Association·Khalid Al-RubeaanAmira M Youssef
Apr 24, 2018·Journal of Clinical Imaging Science·Mehmet B ÇildağDavid G Armstrong
Apr 26, 2017·Annual Review of Neuroscience·Franziska DenkStephen B McMahon
Aug 7, 2018·World Journal of Diabetes·Harsh DurgiaHenith Raj
Oct 4, 2017·Journal of Orthopaedic Surgery and Research·Hong-Mou ZhaoDing-Jun Hao
Oct 22, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·R KeukenkampS A Bus
Jan 9, 2021·Therapeutic Advances in Musculoskeletal Disease·Ivan UritsOmar Viswanath
Aug 27, 2021·The Journal of the American Academy of Orthopaedic Surgeons·Harold ReesNicholas Brown
Nov 23, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Win Min Oo, David J Hunter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.